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Series GSE136636 Query DataSets for GSE136636
Status Public on Sep 18, 2019
Title Understanding the stromal composition of fat-associated lymphoid clusters of the omentum using single-cell transcriptomics
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary We profile the transcriptome of over 4000 murine single cells from the stromal non-endothelial fraction of the omentum. We uncover that the omentum is composed of 2 populations of fibroblasts which differentially express Ccl11 and Ccl19 and three populations of mesothelial cells. One of these mesothelial populations were distinguised by the expression of inflammatory genes and the other one by the expression of anti-viral genes. This study unveil the complexcity of the stromal niche in the omentum and revealed the adaptation of the mesothelium to FALCs function.
Overall design Single-cell transcriptomic data are presented from the pooled omentum of 3 unchallenged mice. Cell were sorted as CD45-Ter119-CD41-CD31-Gp38+
Contributor(s) Smith P, Portman JR, Henderson B, Dobie R, Henderson N, Benezech C
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Submission date Aug 29, 2019
Last update date Jan 29, 2020
Contact name Cecile Benezech
Organization name University of Edinburgh
Department Centre for Cardiovascular Sciences
Street address 47 Little france Crescent
City Edinburgh
ZIP/Postal code EH16 4TJ
Country United Kingdom
Platforms (1)
GPL24247 Illumina NovaSeq 6000 (Mus musculus)
Samples (1)
GSM4053741 Omentum_non_endothelial_stroma
BioProject PRJNA562904
SRA SRP219839

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Supplementary file Size Download File type/resource
GSE136636_RAW.tar 26.6 Mb (http)(custom) TAR (of MTX, TSV)
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Raw data are available in SRA
Processed data provided as supplementary file

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