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| Status |
Public on Aug 26, 2022 |
| Title |
Genome-wide maps of gene transcription level in wild-type and mpbR-deleted Mycobacterium tuberculosis H37Ra strains |
| Organism |
Mycobacterium tuberculosis H37Ra |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
We report the application of RNA-seq technology for high-throughput profiling of gene transcription in M. tuberculosis H37Ra strains. By obtaining over four billion bases of sequence from mRNA, we generated genome-wide gene transcription maps of wild-type and mpbR-deleted Mycobacterium tuberculosis H37Ra strains. We find that a group of genes is significantly up-regulated in the mpbR-deleted mutant strain. This finding indicates that MpbR negatively regulates gene expression.
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| |
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| Overall design |
Examination of gene expression level in 2 strains.
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| |
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| Contributor(s) |
He Z, Li Y |
| Citation missing |
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| |
| Submission date |
Aug 26, 2019 |
| Last update date |
Aug 26, 2022 |
| Contact name |
Yugang Li |
| E-mail(s) |
xuhui123@web.mail.hzau.edu.cn
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| Organization name |
Huazhong Agricultural University
|
| Street address |
shizishan street
|
| City |
WuHan |
| ZIP/Postal code |
430070 |
| Country |
China |
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| Platforms (1) |
| GPL27144 |
Illumina HiSeq 2500 (Mycobacterium tuberculosis H37Ra) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA562277 |
| SRA |
SRP219299 |
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