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| Status |
Public on Aug 24, 2019 |
| Title |
A combined epigenome- and transcriptome-wide association study of the oral masticatory mucosa assigns CYP1B1 a central role for epithelial health in smokers |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Healthy ex vivo biopsies from masticatory mucosa from 17 current and 21 never smokers were analysed using whole transcriptome RNA sequencing (16 mio reads/sample), showing significantly increased expression of CYP1B1 in smokers compared to non-smokers (p = 2.2 × 10−14), together with 13 significantly upregulated transcripts. Six transcripts were significantly downregulated.
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| |
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| Overall design |
mRNA profiles of ex vivo masticatory mucosa from 17 current smokers and 21 never smokers
|
| |
|
| Contributor(s) |
Richter GM, Schaefer AS |
| Citation(s) |
31331382 |
| Submission date |
Aug 23, 2019 |
| Last update date |
Aug 29, 2019 |
| Contact name |
Gesa Marijke Richter |
| E-mail(s) |
gesa.richter@charite.de
|
| Organization name |
Charité - University Medicine Berlin
|
| Street address |
Assmannshauser Str. 4-6
|
| City |
Berlin |
| ZIP/Postal code |
14197 |
| Country |
Germany |
| |
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| Platforms (1) |
| GPL21290 |
Illumina HiSeq 3000 (Homo sapiens) |
|
| Samples (38)
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| Relations |
| BioProject |
PRJNA561777 |
| SRA |
SRP219430 |
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