|
| Status |
Public on Aug 30, 2019 |
| Title |
SCDC: Deconvolution of Bulk Gene Expression by Single-Cell RNA Sequencing Data |
| Organisms |
Homo sapiens; Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
This paper describes SCDC, a deconvolution method for bulk RNA-seq that leverages cell-type specific gene expression profiles from multiple scRNA-seq reference datasets.
|
| |
|
| Overall design |
SCDC adopts an ENSEMBLE method to integrate deconvolution results from different scRNA-seq datasets produced in different conditions, implicitly addressing the batch-effect confounding.
|
| |
|
| Contributor(s) |
Perou CM, Thennavan A |
| Citation(s) |
31925417, 34412669 |
| |
| Submission date |
Aug 21, 2019 |
| Last update date |
Aug 31, 2021 |
| Contact name |
Charles M. Perou |
| E-mail(s) |
cperou@med.unc.edu
|
| Organization name |
University of North Carolina at Chapel Hill
|
| Department |
Professor of Genetics, and Pathology & Laboratory Medicine; Lineberger Comprehensive Cancer Center
|
| Street address |
12-044 Lineberger Comprehensive Cancer Center CB# 7295
|
| City |
Chapel Hill |
| State/province |
NC |
| ZIP/Postal code |
27599-7264 |
| Country |
USA |
| |
|
| Platforms (4)
|
| GPL16791 |
Illumina HiSeq 2500 (Homo sapiens) |
| GPL17021 |
Illumina HiSeq 2500 (Mus musculus) |
| GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
| GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
|
| Samples (8)
|
|
| Relations |
| BioProject |
PRJNA561378 |
| SRA |
SRP219023 |
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