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Series GSE136040 Query DataSets for GSE136040
Status Public on Feb 24, 2020
Title LncRNA LUCRC regulates colorectal cancer cell proliferation and tumorigenesis by targeting endoplasmic reticulum stress response
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Colorectal cancer (CRC) is the second most common cause of cancer-related death worldwide, and is well known for its strong invasiveness, rapid recurrence and poor prognosis. Long non-coding RNAs (lncRNAs) have been shown to be involved in the development of variety types of cancers, including colorectal cancer. Here, through transcriptomic analysis and functional screening, we reported that lncRNA LUCRC (LncRNA Upregulated in Colorectal Cancer) is highly expressed in colorectal tumor samples and is required for colorectal cancer cell proliferation, migration and invasion in cultured cells and tumorigenesis in xenografts. LUCRC was found to regulate target gene expression of unfolded protein response (UPR) in endoplasmic reticulum (ER), such as BIP. The clinical significance of LUCRC is underscored by the specific presence of LUCRC in blood plasma of patients with colorectal cancers. These findings revealed a critical regulator of colorectal cancer development, which might serve as a therapeutic target in colorectal cancer.
Overall design RNA-seq was performed to identify target genes of a lncRNA termed LUCRC in colorectal cancer cell HCT116.
Contributor(s) Liu W, Ding J, Chen X
Citation(s) 32082365
Submission date Aug 20, 2019
Last update date Feb 24, 2020
Contact name Jiancheng Ding
Organization name Xiamen University
Street address School of Pharmaceutical Sciences, Xiamen University Xiang`an South Road
City Xiamen
State/province Fujian
ZIP/Postal code 361102
Country China
Platforms (2)
GPL21290 Illumina HiSeq 3000 (Homo sapiens)
GPL24676 Illumina NovaSeq 6000 (Homo sapiens)
Samples (4)
GSM4039939 RNA-Seq_HCT116_siCTL
GSM4039940 RNA-Seq_HCT116_siLUCRC
GSM4217843 RNA-Seq_HCT116_siCTLrep
BioProject PRJNA561081
SRA SRP218870

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Supplementary file Size Download File type/resource
GSE136040_RAW.tar 1.2 Gb (http)(custom) TAR (of BIGWIG)
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Raw data are available in SRA
Processed data provided as supplementary file

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