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Series GSE135939 Query DataSets for GSE135939
Status Public on Aug 19, 2019
Title microRNA expression data from nucleated cells excluding tumor cells in malignant pleural effusion (MPE) from WT and IL-10 knock out (IL-10-/-)
Platform organism synthetic construct
Sample organism Mus musculus
Experiment type Expression profiling by array
Summary The interactions between tumor cells and the host vasculature and immune cells results in increased net fluid production via enhanced plasma extravasation into the pleural space.Understanding the regulatory mechanism of IL-10 in MPE formation is essential both for deciphering how IL-10 acts in regulating tumor immunity and for discovering key molecular targets for intervention in advanced cancers.
We investigate the characteristic of microRNAs (miRNAs) in IL-10 induced murine MPE. Identifing the distinct classes of up-regulated and down-regulated miRNAs during this process.
Overall design The nucleated cells, excluding tumor cells, from MPE of WT and IL-10-/- mice were collected for RNA extraction.The miRNA profiles of these cells were detected using GeneChip® miRNA 4.0 Array (Affymetrix, Santa Clara, CA).
Contributor(s) Shi X, Zhai K, Shi H
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Submission date Aug 18, 2019
Last update date Aug 21, 2019
Contact name Xin-Yu Shi
Phone 86 18810677155
Organization name Beijing Chao-yang hospital
Street address Gongti Nan Road
City Beijing
ZIP/Postal code 100020
Country China
Platforms (1)
GPL19117 [miRNA-4] Affymetrix Multispecies miRNA-4 Array
Samples (6)
GSM4038104 Nucleated cells excluding tumor cells from MPE of IL-10-/- mice, biological rep1
GSM4038105 Nucleated cells excluding tumor cells from MPE of IL-10-/- mice, biological rep2
GSM4038106 Nucleated cells excluding tumor cells from MPE of IL-10-/- mice, biological rep3
BioProject PRJNA560690

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Supplementary file Size Download File type/resource
GSE135939_RAW.tar 3.7 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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