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| Status |
Public on Mar 13, 2024 |
| Title |
Changes in cellular transcriptome in response to inhibitors of Epstein-Barr virus |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Burkitt lymphoma cells can be latently infected with Epstein-Barr virus (EBV). The virus may be activated into its lytic cycle by small molecules, such as sodium butyrate. Other molecules, such as valproate and valpromide, block viral lytic reactivation. These pharmacological agents alter the cellular physiology that controls viral lytic gene expression. Changes in the cellular transcription were measured in response to one activator and two inhibitors of the Epstein-Barr virus lytic cycle in order to identify cellular genes that are potential regulators of the viral life cycle.
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| Overall design |
RNA-seq transcriptome analysis of EBV-positive Burkitt lymphoma cells treated for 6 hours with DMSO (control), butyrate (3 mM), valproate (10 mM), valpromide (10 mM), valproate plus butyrate, or valpromide plus butyrate. Each condition was performed in duplicate.
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| Contributor(s) |
Gorres KL, Reineke D, Miller G |
| Citation(s) |
38635661 |
| |
| Submission date |
Aug 13, 2019 |
| Last update date |
Apr 18, 2024 |
| Contact name |
Kelly Gorres |
| Organization name |
University of Wisconsin-La Crosse
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| Department |
Chemistry & Biochemistry
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| Street address |
1725 State St, Cowley 4015
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| City |
La Crosse |
| State/province |
WI |
| ZIP/Postal code |
54601 |
| Country |
USA |
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| Platforms (1) |
| GPL11154 |
Illumina HiSeq 2000 (Homo sapiens) |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA560076 |
| SRA |
SRP218256 |
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