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Series GSE135759 Query DataSets for GSE135759
Status Public on Oct 27, 2020
Title MiRNA-mediated regulation of Bmp2 during pathological calcification
Platform organism synthetic construct
Sample organism Mus musculus
Experiment type Non-coding RNA profiling by array
Summary Renal disease is a major risk factor for cardiovascular disease. BMP2 and its downstream effectors are strong implicators of pathological calcificatoin.
We profiled miRNAs from Klotho mutant mice and from health mice to determine any potential biomarkers for predicting the progression of pathological calcification through targeting of BMP2 and its downstream effectors.
Overall design 1908 miRNA levels measured from 19 mice. Klotho homozygotes (Klkl/kl) exhibited the full phenotype with aortic calcification. Control mice with the wild type (Kl+/+) or heterozygous (Kl+/kl) Klotho genotypes were healthy and indistinguishable.
Contributor(s) Shah TA, Tang Y, Rogers MB
Citation(s) 32956022
Submission date Aug 12, 2019
Last update date Oct 29, 2020
Contact name Melissa B. Rogers
Phone 9739722984
Organization name Rutgers NJMS
Department Biochem. & Molec. Biology
Lab MSB E627
Street address 185 south orange ave.
City Newark
State/province NJ
ZIP/Postal code 07103
Country USA
Platforms (1)
GPL19117 [miRNA-4] Affymetrix Multispecies miRNA-4 Array
Samples (19)
GSM4027706 KT266: Aorta_Male_Klotho_Homozygote_rep 1
GSM4027707 KT267: Aorta_Male_Control_rep 1
GSM4027708 KT268: Aorta_Male_Control_rep 2
BioProject PRJNA559924

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE135759_RAW.tar 14.3 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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