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| Status |
Public on Aug 07, 2023 |
| Title |
Gene-expression profiling in pancreatic cancer cells treated with macrophage conditioned media and etomoxir |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
The study aims to show that a metabolic shift is a precondition for the initiation of an invasive/metastatic program in pancreatic cancer. Paracrine cues and metabolic stress (mimicked in vitro by treatment with macrophage-conditioned media and low dose etomoxir) regularly found in the metastasis-promoting tumor stroma consistently induced transcriptional changes resulting in the acquisition of migratory and invasive abilities.
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| Overall design |
Samples from primary cultures corresponding to 3 different patient-derived xenografts either untreated (CONT, used as reference for each Pdx) or treated for 48h with macrophage conditioned media (MCM) or low-dose etomoxir (ETO), in duplicate.
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| Contributor(s) |
Parejo-Alonso B, Lin M, Heeschen C, Sancho P |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Aug 10, 2019 |
| Last update date |
Aug 07, 2023 |
| Contact name |
Patricia Sancho |
| E-mail(s) |
psancho@iisaragon.es
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| Organization name |
Hospital Miguel Servet IIS Aragón
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| Department |
Traslational Research Unit
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| Lab |
Metabolism & Cancer Stem Cells
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| Street address |
P. Isabel la Católica 1-3
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| City |
Zaragoza |
| State/province |
Aragón |
| ZIP/Postal code |
50009 |
| Country |
Spain |
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| Platforms (1) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
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| Samples (18)
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| Relations |
| BioProject |
PRJNA559667 |
| SRA |
SRP218017 |
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