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Series GSE135686 Query DataSets for GSE135686
Status Public on Aug 07, 2023
Title Gene-expression profiling in pancreatic cancer cells treated with macrophage conditioned media and etomoxir
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary The study aims to show that a metabolic shift is a precondition for the initiation of an invasive/metastatic program in pancreatic cancer. Paracrine cues and metabolic stress (mimicked in vitro by treatment with macrophage-conditioned media and low dose etomoxir) regularly found in the metastasis-promoting tumor stroma consistently induced transcriptional changes resulting in the acquisition of migratory and invasive abilities.
Overall design Samples from primary cultures corresponding to 3 different patient-derived xenografts either untreated (CONT, used as reference for each Pdx) or treated for 48h with macrophage conditioned media (MCM) or low-dose etomoxir (ETO), in duplicate.
Contributor(s) Parejo-Alonso B, Lin M, Heeschen C, Sancho P
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Submission date Aug 10, 2019
Last update date Aug 07, 2023
Contact name Patricia Sancho
Organization name Hospital Miguel Servet IIS Aragón
Department Traslational Research Unit
Lab Metabolism & Cancer Stem Cells
Street address P. Isabel la Católica 1-3
City Zaragoza
State/province Aragón
ZIP/Postal code 50009
Country Spain
Platforms (1)
GPL24676 Illumina NovaSeq 6000 (Homo sapiens)
Samples (18)
GSM4026060 C354_CONT (S787Nr4)
GSM4026061 C354_MCM (S787Nr5)
GSM4026062 C354_ETO (S787Nr6)
BioProject PRJNA559667
SRA SRP218017

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE135686_S787_raw_sequence_readcount.csv.gz 978.6 Kb (ftp)(http) CSV
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Raw data are available in SRA
Processed data are available on Series record

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