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Series GSE135478 Query DataSets for GSE135478
Status Public on Oct 17, 2019
Title PTENa/b paradoxically promote carcinogenesis through WDR5-H3K4me3 axis [ChIP-seq 2]
Organism Homo sapiens
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary We report that USP9X and FBXW11 selectively regulate the stability of PTENa/b but not PTEN proteins by deubiquitination and ubiquitination respectively. USP9X promotes and FBXW11 suppresses tumorigenesis mediated by PTENa/b. In contrast to the current paradigm for PTEN as a tumor suppressor, PTENa/b promote tumorigenesis of cancer cells in a phosphatase-independent manner. Mechanistically, PTENa/b localized in the nucleus regulate expressions of tumor-promoting genes such as NOTCH3 in the similar way as the H3K4 presenter WDR5. Further, PTENa/b but not PTEN directly interact with WDR5 to promote trimethylation of H3K4 and maintain a tumor-promoting signature.
Overall design To investigate the influence of H3K4me3 at gene promoters with or without PTENa/b depletion by ChIP seq in SMMC-7721.
Contributor(s) Shen SM, Zhang C, Ge MK, Dong SS
Citation(s) 31685992
Submission date Aug 06, 2019
Last update date Jan 16, 2020
Contact name ge mengkai
Phone 15201867201
Organization name Shanghai Jiao Tong University School of Medicine (SJTU-SM)
Street address shanghai
City shanghai
State/province State...
ZIP/Postal code 13185541251gmk
Country China
Platforms (1)
GPL24676 Illumina NovaSeq 6000 (Homo sapiens)
Samples (4)
GSM4011081 ChIP-gNS_FRRC190665538-1a
GSM4011082 ChIP-gPTENL_FRRC190665539-1a
GSM4011083 Input-gNS_FRRC190665536-1a
This SubSeries is part of SuperSeries:
GSE126984 PTEN╬▒/╬▓ paradoxically promote carcinogenesis through WDR5-H3K4me3 axis
BioProject PRJNA559009
SRA SRP217603

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Supplementary file Size Download File type/resource 232.8 Mb (ftp)(http) BW 256.3 Mb (ftp)(http) BW
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