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Series GSE135416 Query DataSets for GSE135416
Status Public on Oct 27, 2021
Title Role of transcription factor ONECUT1 (HNF6) during in vitro pancreatic differentiation of human pluripotent stem cells [RNA-seq]
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary We have identified HNF6 as an essential transcription factor for endocrine pancreatic development. HNF6 binds to and possibly regulates other isletogenesis transcription factors, driving endocrine differentiation. RNA sequencing of control and HNF6-depleted hESC during in vitro pancreatic differentiation will help to understand the regulatory mechanisms during cell fate decisions.
 
Overall design The human embryonic stem cell line HUES8 differentiated to definitive endoderm, pancreatic endoderm and pancreatic progenitor cells was used for RNA sequencing.
 
Contributor(s) Kwon G, Li Z, Costa IG, Kleger A, Heller S
Citation(s) 34663987
Submission date Aug 05, 2019
Last update date Jan 26, 2022
Contact name Ivan Costa
E-mail(s) ivan.costa@rwth-aachen.de
Organization name Unikilink RWTH Aachen
Lab Computational Biology
Street address PauwelsstraƟe 19
City Aachen
ZIP/Postal code 52074
Country Germany
 
Platforms (1)
GPL21290 Illumina HiSeq 3000 (Homo sapiens)
Samples (84)
GSM4008425 Con_ESC_Rep1
GSM4008426 Con_ESC_Rep2
GSM4008427 Con_ESC_Rep3
This SubSeries is part of SuperSeries:
GSE131817 Role of transcription factor ONECUT1 during in vitro pancreatic differentiation of human pluripotent stem cells
Relations
BioProject PRJNA558795
SRA SRP217514

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE135416_Global_FPKM.txt.gz 19.0 Mb (ftp)(http) TXT
GSE135416_Global_VST_model_count.txt.gz 17.4 Mb (ftp)(http) TXT
GSE135416_RAW.tar 1.3 Gb (http)(custom) TAR (of BW)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file
Processed data are available on Series record

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