GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
Series GSE135404 Query DataSets for GSE135404
Status Public on Aug 01, 2022
Title Fine-Tuning of PGC1α Expression Regulates Cardiac Function and Longevity (RNA-seq: telomerase-deficient vs PGC1aOE)
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary PGC1alpha plays an important role in energy metabolism and mitochondrial function in the heart, multiple attempts have failed to upregulate PGC1alpha expression as a therapy, with the underlying mechanism to be answered. We used RNA sequencing to detail the global programme of gene expression in the hearts of third generation of telomerase-deficient mice with or without cardiomyocyte-restricted PGC1alpha overexpression.
Overall design Heart mRNA profiles of 12-month old telomerase-deficient (G3) and PGC1alpha overexpressed G3 mice were generated by deep sequencing, using Illumina HiSeq.
Contributor(s) Zhu X, Ju Z
Citation missing Has this study been published? Please login to update or notify GEO.
Submission date Aug 05, 2019
Last update date Aug 01, 2022
Contact name Xudong Zhu
Organization name Hangzhou Normal University
Street address #2318 Yuhangtang Road
City Hangzhou
ZIP/Postal code 311121
Country China
Platforms (1)
GPL21273 HiSeq X Ten (Mus musculus)
Samples (7)
GSM4007708 G3 1
GSM4007709 G3 2
GSM4007710 G3 3
This SubSeries is part of SuperSeries:
GSE136787 Fine-Tuning of PGC1α Expression Regulates Cardiac Function and Longevity
BioProject PRJNA558760
SRA SRP217504

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE135404_fpkm.txt.gz 724.9 Kb (ftp)(http) TXT
GSE135404_readcount.txt.gz 262.0 Kb (ftp)(http) TXT
SRA Run SelectorHelp
Raw data are available in SRA
Processed data are available on Series record

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap