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Series GSE135378 Query DataSets for GSE135378
Status Public on Jun 30, 2021
Title RNA-seq of DNMT1 inhibitor treated AML cell lines
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Genome wide demethylation by DNMT1 inhibitors GSK3685032 results in up-regulation of epigenetically-silenced genes.
Overall design Differential expression was perfomed for each cell line following DNMT1 inhibitor or vehicle treatment across 6 point dose titration and 6 day timecourse. Differentially epressed gene lists were compared across the dose and timecourse.
Web link
Contributor(s) Pappalardi MB, McCabe MT, Kellner WA, Keenan K
Citation(s) 34790902
Submission date Aug 05, 2019
Last update date Nov 30, 2021
Contact name Shawn W Foley
Organization name GlaxoSmithKline
Department Oncology
Street address 1250 S. Collegeville Rd
City Collegeville
State/province PA
ZIP/Postal code 19426
Country USA
Platforms (1)
GPL24676 Illumina NovaSeq 6000 (Homo sapiens)
Samples (156)
GSM4007051 MV411.0nM.DMSO.d1.n1 [S1-01]
GSM4007052 MV411.400nM.GSK032.d1.n1 [S1-02]
GSM4007053 MV411.400nM.DAC.d1.n1 [S1-03]
This SubSeries is part of SuperSeries:
GSE135207 Expression profiling and methylation analysis of DNMT1 inhibitor treated AML cell lines
BioProject PRJNA558691
SRA SRP217480

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SOFT formatted family file(s) SOFTHelp
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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE135378_DNMT1_AML_MV411_lfc_table.txt.gz 5.1 Mb (ftp)(http) TXT
GSE135378_DNMT1_AML_NOMO1_lfc_table.txt.gz 4.8 Mb (ftp)(http) TXT
GSE135378_DNMT1_AML_THP1_lfc_table.txt.gz 5.1 Mb (ftp)(http) TXT
GSE135378_DNMT1_AML_fpkm_MV411_table.txt.gz 9.2 Mb (ftp)(http) TXT
GSE135378_DNMT1_AML_fpkm_NOMO1_table.txt.gz 9.1 Mb (ftp)(http) TXT
GSE135378_DNMT1_AML_fpkm_THP1_table.txt.gz 9.6 Mb (ftp)(http) TXT
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Raw data are available in SRA
Processed data are available on Series record

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