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Series GSE135343 Query DataSets for GSE135343
Status Public on Aug 02, 2022
Title circRNA sequencing facilitates quantitative analysis of CUS mice hippocampus and Control mice hippocampus
Organism Mus musculus
Experiment type Non-coding RNA profiling by high throughput sequencing
Summary The goal of this study is to seek the potential circular RNAs (circRNAs), which express differently between control group and chronic unpredictable stress (CUS) group mouse hippocampus, involved in major dipresssion disorder (MDD) by high-throughput sequencing. QPCR was preformed to identify the circRNAs trend. CircRNAs are a class of RNAs in the eukaryotic transcriptome. The function and explicit downstream mechanisms of circRNA regulated in maior depression disorser remain unclear. To further investigate the potential role of circRNAs in MDD, we performed human and mouse homology screening on circRNA sequences using the Basic Local Alignment Search Tool on the NCBI website. CircSTAG1, a homologous human and mouse circRNA, was found downregulated in circRNA high-throughput sequencing. Our study represents the first detailed analysis of circRNA expressing differently in CUS mouse hippocampus by high-throughput sequencing.
Overall design CUS induced circular RNA expression in mice hippocampus was measured, and their expression in healthy controls were set as comparison. Three independent samples from CUS group and three independent samples from control group were employed in high-throughput sequencing analysis.
Contributor(s) Yao H, Huang R
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Submission date Aug 03, 2019
Last update date Aug 02, 2022
Contact name Rongrong Huang
Phone 15905173096
Organization name Southeast University
Street address 87 Dingjiaqiao
City Nanjing
State/province Jiangsu
ZIP/Postal code 210009
Country China
Platforms (1)
GPL24247 Illumina NovaSeq 6000 (Mus musculus)
Samples (6)
GSM4006690 Control Mus hippocampus 1
GSM4006691 Control Mus hippocampus 2
GSM4006692 Control Mus hippocampus 3
BioProject PRJNA558498

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE135343_HRR_circRNA_expression.csv.gz 153.9 Kb (ftp)(http) CSV
Raw data are available in SRA
Processed data are available on Series record

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