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Series GSE135318 Query DataSets for GSE135318
Status Public on Aug 01, 2020
Title DOT1L-mediated Murine Neuronal Differentiation associates with H3K79me2 Accumulation and preserves SOX2-Enhancer Accessibility
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Genome binding/occupancy profiling by high throughput sequencing
Summary To study whether acute inhibition of DOT1L induces global chromatin states alterations, we profile and compare the transcriptome, chromatin accessibility and epigenome (H3K4me3, H3K4me1, H3K27ac, H3K27me3, H3K36me3, H3K9me3, H3K79me2) of mESC and ES-derived NPC, treated with DMSO or EPZ5676.
Overall design full epigenome (duplicates), transcriptome (triplicates) and chromatin acceccibility profiling (duplicates) of mouse embryonic stem cells and in-vitro differentiated neurons, treated with DMSO and EPZ5676
Contributor(s) Ferrari F, Arrigoni L, Trompouki E, Vogel T, Manke T
Citation(s) 33060580
Submission date Aug 02, 2019
Last update date Nov 02, 2020
Contact name Thomas Manke
Organization name Max Planck Institute of Immunobiology and Epigenetics
Street address Stuebeweg 51
City Freiburg
ZIP/Postal code 79108
Country Germany
Platforms (2)
GPL21493 Illumina HiSeq 3000 (Mus musculus)
GPL24247 Illumina NovaSeq 6000 (Mus musculus)
Samples (86)
GSM4005176 mESC_DMSO_H3K27ac_rep1
GSM4005177 mESC_DMSO_H3K27ac_rep2
GSM4005178 mESC_DMSO_H3K27me3_rep1
BioProject PRJNA558383
SRA SRP217223

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE135318_RAW.tar 8.5 Gb (http)(custom) TAR (of BW)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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