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Series GSE134956 Query DataSets for GSE134956
Status Public on Aug 14, 2019
Title Dynamic changes of muscle insulin sensitivity after metabolic surgery II
Organism Homo sapiens
Experiment type Expression profiling by array
Summary The mechanisms underlying improved insulin sensitivity after surgically-induced weight loss are still unclear. We monitored skeletal muscle metabolism in obese individuals before and over 52 weeks after metabolic surgery. Initial weight loss occurs in parallel with a decrease in muscle oxidative capacity and respiratory control ratio. Persistent elevation of intramyocellular lipid intermediates, likely resulting from unrestrained adipose tissue lipolysis, accompanies the lack of rapid changes in insulin sensitivity. Simultaneously, alterations in skeletal muscle expression of genes involved in calcium/lipid metabolism and mitochondrial function associate with subsequent distinct DNA methylation patterns at 52 weeks after surgery. Thus, initial unfavorable metabolic changes including insulin resistance of adipose tissue and skeletal muscle precede epigenetic modifications of genes involved in muscle energy metabolism and the long-term improvement of insulin sensitivity.
 
Overall design This study includes 1 control and 7 obese participants. Gene expression from obese persons was measured 3 times: before, 2 weeks and 52 weeks after metabolic surgery
 
Contributor(s) Ouni M, Jähnert M, Gancheva S, Roden M, Schürmann A
Citation(s) 31519890
Submission date Jul 26, 2019
Last update date Jun 17, 2020
Contact name Annette Schürmann
E-mail(s) schuermann@dife.de
Organization name German Institute of Human Nutrition Potsdam-Rehbruecke
Department Department of Experimental Diabetology
Street address Arthur-Scheunert-Allee 114-116
City Nuthetal
State/province BRB
ZIP/Postal code 14558
Country Germany
 
Platforms (1)
GPL26966 Agilent-079407 ArrayXS Human V3 079025 [PROBE NAME]
Samples (8)
GSM3980363 BAR-MV42_T0
GSM3980364 BAR-MV42_T2wks
GSM3980365 BAR-MV42_T52wks
This SubSeries is part of SuperSeries:
GSE135066 Dynamic changes of muscle insulin sensitivity after metabolic surgery
Relations
BioProject PRJNA557236

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE134956_RAW.tar 80.9 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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