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Series GSE134805 Query DataSets for GSE134805
Status Public on Apr 11, 2020
Title Biological sex influences susceptibility to Acinetobacter baumannii pneumonia in mice
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Through our studies using a murine model of acute pneumonia with A. baumannii, we observed that female mice were more susceptible to infection. Likewise, treatment of male mice with estradiol increased their susceptibility to infection. Analysis of the airway compartment revealed enhanced inflammation and reduced neutrophil and alveolar macrophage numbers compared to male mice. Depletion of either neutrophils or alveolar macrophages was important for bacterial clearance however, depletion of alveolar macrophages further exacerbated female susceptibility due to severe alterations in metabolic homoeostasis.
Overall design RNA was extracted from lung homogenates of female and male mice depleted of alveolar macrophages following a 4 h infection with Acinetobacter baumannii
Contributor(s) Pires S, Parker D
Citation(s) 32191638
Submission date Jul 24, 2019
Last update date Apr 11, 2020
Contact name Dane Parker
Phone 9739723047
Organization name Rutgers New Jersey Medical School
Department Pathology, Immunology and Laboratory Medicine
Street address 205 South Organge Ave, G-1208
City Newark
State/province NJ
ZIP/Postal code 07103
Country USA
Platforms (1)
GPL24247 Illumina NovaSeq 6000 (Mus musculus)
Samples (13)
GSM3971336 clodronate male Ab1
GSM3971337 clodronate male Ab2
GSM3971338 clodronate male Ab3
BioProject PRJNA556453
SRA SRP216262

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Supplementary file Size Download File type/resource
GSE134805_clodronate_infected.xlsx 209.8 Kb (ftp)(http) XLSX
GSE134805_clodronate_uninfected.xlsx 24.0 Kb (ftp)(http) XLSX
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