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| Status |
Public on Apr 11, 2020 |
| Title |
Biological sex influences susceptibility to Acinetobacter baumannii pneumonia in mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Through our studies using a murine model of acute pneumonia with A. baumannii, we observed that female mice were more susceptible to infection. Likewise, treatment of male mice with estradiol increased their susceptibility to infection. Analysis of the airway compartment revealed enhanced inflammation and reduced neutrophil and alveolar macrophage numbers compared to male mice. Depletion of either neutrophils or alveolar macrophages was important for bacterial clearance however, depletion of alveolar macrophages further exacerbated female susceptibility due to severe alterations in metabolic homoeostasis.
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| Overall design |
RNA was extracted from lung homogenates of female and male mice depleted of alveolar macrophages following a 4 h infection with Acinetobacter baumannii
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| |
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| Contributor(s) |
Pires S, Parker D |
| Citation(s) |
32191638 |
| |
| Submission date |
Jul 24, 2019 |
| Last update date |
Apr 11, 2020 |
| Contact name |
Dane Parker |
| E-mail(s) |
dane.parker@rutgers.edu
|
| Phone |
9739723047
|
| Organization name |
Rutgers New Jersey Medical School
|
| Department |
Pathology, Immunology and Laboratory Medicine
|
| Street address |
205 South Organge Ave, G-1208
|
| City |
Newark |
| State/province |
NJ |
| ZIP/Postal code |
07103 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (13)
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| Relations |
| BioProject |
PRJNA556453 |
| SRA |
SRP216262 |
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