|
| Status |
Public on Aug 08, 2019 |
| Title |
Transcriptomic profile of Pdk2KO mice treated with RGLS4326 |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Kidney global mRNA expression profiles was carried out in the Pkd2-KO model following RGLS4326 treatment PBS-treated controls. We found that RGLS4326 treatment had a significant transcriptome-wide impact and globally de-repressed mRNAs of predicted miR-17 target genes in cystic kidneys of Pkd2-KO model
|
| |
|
| Overall design |
Pkd2-KO mice were randomly assigned and dosed with RGLS4326 (20 mg kg-1) or PBS by SC injections at post natal day (P)10, 11,12 and 19. Non-transgenic strain-matched mice were used for comparison. All animals were euthanized, and kidney harvested at P28 .
|
| |
|
| Contributor(s) |
Gatto S, Valencia T, Lee EC, Patel V |
| Citation(s) |
31515477 |
| |
| Submission date |
Jul 23, 2019 |
| Last update date |
Sep 23, 2019 |
| Contact name |
Sole Gatto |
| E-mail(s) |
sole.gattov1.0@gmail.com
|
| Organization name |
Monoceros Biosystems
|
| Street address |
12636 High Bluff Drive, Suite 400
|
| City |
San Diego |
| State/province |
CA |
| ZIP/Postal code |
92130 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
|
| Samples (34)
|
|
| This SubSeries is part of SuperSeries: |
| GSE134721 |
Transcriptomic profiles of Pcy and Pdk2KO mice and human kidney epithelial cells treated with RGLS4326 |
|
| Relations |
| BioProject |
PRJNA556224 |
| SRA |
SRP216037 |
Less...
More...