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| Status |
Public on Aug 08, 2019 |
| Title |
Transcriptomic profile of Pcy mice treated with RGLS4326 |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Kidney global mRNA expression profiles was carried out in the Pcy/CD1 model following RGLS4326 treatment versus PBS-treated controls. We found that RGLS4326 treatment had a significant transcriptome-wide impact and globally de-repressed mRNAs of predicted miR-17 target genes in cystic kidneys of Pcy/CD1 model
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| Overall design |
5-weeks old mice were randomly assigned and dosed with RGLS4326 (25 mg kg-1) or PBS by SC injections once- monthly (Q4W) for 25 weeks. All animals were euthanized, and kidney harvested at 30 weeks of age. Five untreated male WT/CD1 mice were included for comparison.
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| Contributor(s) |
Gatto S, Valencia T, Lee EC, Kersjes K |
| Citation(s) |
31515477 |
| |
| Submission date |
Jul 23, 2019 |
| Last update date |
Sep 23, 2019 |
| Contact name |
Sole Gatto |
| E-mail(s) |
sole.gattov1.0@gmail.com
|
| Organization name |
Monoceros Biosystems
|
| Street address |
12636 High Bluff Drive, Suite 400
|
| City |
San Diego |
| State/province |
CA |
| ZIP/Postal code |
92130 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
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| Samples (31)
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| This SubSeries is part of SuperSeries: |
| GSE134721 |
Transcriptomic profiles of Pcy and Pdk2KO mice and human kidney epithelial cells treated with RGLS4326 |
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| Relations |
| BioProject |
PRJNA556227 |
| SRA |
SRP216039 |
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