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Status |
Public on Dec 05, 2019 |
Title |
RNA-seq profiling of adult skeletal muscle after long term conditional knockout of Hic1 [TA RNA-seq] |
Organism |
Mus musculus |
Experiment type |
Expression profiling by high throughput sequencing
|
Summary |
To determine the effects of long term deletion of the transcriptional repressor Hypermethylated in cancer 1 (Hic1) on skeletal muscle, samples were collected of both wild type mice and those conditionally deleted for Hic1 and profiled by RNA sequencing. Aspects of muscle homeostasis were negatively impacted, highlighting cell and non cell autonomous roles for Hic1 in maintaining functional MPs and muscle tissue.
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Overall design |
Transcriptome wide profiling of skeletal muscle of aged wild type and Hic1-/- mice, n > 7.
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Contributor(s) |
Scott RW, Underhill TM |
Citation(s) |
31809738 |
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Submission date |
Jul 08, 2019 |
Last update date |
Feb 19, 2020 |
Contact name |
Tully Michael Underhill |
E-mail(s) |
tunderhi@brc.ubc.ca
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Phone |
604-822-5833
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Organization name |
University of British Columbia
|
Department |
Biomedical Research Centre
|
Street address |
2222 Health Sciences Mall
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City |
Vancouver |
State/province |
British Columbia |
ZIP/Postal code |
V6T 1Z3 |
Country |
Canada |
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Platforms (1) |
GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
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Samples (16)
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GSM3932061 |
RNA-seq wildtype replicate 1 [TA RNA-seq] |
GSM3932062 |
RNA-seq wildtype replicate 2 [TA RNA-seq] |
GSM3932063 |
RNA-seq wildtype replicate 3 [TA RNA-seq] |
GSM3932064 |
RNA-seq wildtype replicate 4 [TA RNA-seq] |
GSM3932065 |
RNA-seq wildtype replicate 5 [TA RNA-seq] |
GSM3932066 |
RNA-seq wildtype replicate 6 [TA RNA-seq] |
GSM3932067 |
RNA-seq wildtype replicate 7 [TA RNA-seq] |
GSM3932068 |
RNA-seq knockout replicate 1 [TA RNA-seq] |
GSM3932069 |
RNA-seq knockout replicate 2 [TA RNA-seq] |
GSM3932070 |
RNA-seq knockout replicate 3 [TA RNA-seq] |
GSM3932071 |
RNA-seq knockout replicate 4 [TA RNA-seq] |
GSM3932072 |
RNA-seq knockout replicate 5 [TA RNA-seq] |
GSM3932073 |
RNA-seq knockout replicate 6 [TA RNA-seq] |
GSM3932074 |
RNA-seq knockout replicate 7 [TA RNA-seq] |
GSM3932075 |
RNA-seq knockout replicate 8 [TA RNA-seq] |
GSM3932076 |
RNA-seq knockout replicate 9 [TA RNA-seq] |
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This SubSeries is part of SuperSeries: |
GSE110038 |
Hic1 defines quiescent mesenchymal progenitor subpopulations with distinct functions and fates in skeletal muscle regeneration |
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Relations |
BioProject |
PRJNA553290 |
SRA |
SRP213792 |