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Series GSE133995 Query DataSets for GSE133995
Status Public on Dec 05, 2019
Title RNA-seq profiling of adult skeletal muscle after long term conditional knockout of Hic1 [TA RNA-seq]
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary To determine the effects of long term deletion of the transcriptional repressor Hypermethylated in cancer 1 (Hic1) on skeletal muscle, samples were collected of both wild type mice and those conditionally deleted for Hic1 and profiled by RNA sequencing. Aspects of muscle homeostasis were negatively impacted, highlighting cell and non cell autonomous roles for Hic1 in maintaining functional MPs and muscle tissue.
 
Overall design Transcriptome wide profiling of skeletal muscle of aged wild type and Hic1-/- mice, n > 7.
 
Contributor(s) Scott RW, Underhill TM
Citation(s) 31809738
Submission date Jul 08, 2019
Last update date Feb 19, 2020
Contact name Tully Michael Underhill
E-mail(s) tunderhi@brc.ubc.ca
Phone 604-822-5833
Organization name University of British Columbia
Department Biomedical Research Centre
Street address 2222 Health Sciences Mall
City Vancouver
State/province British Columbia
ZIP/Postal code V6T 1Z3
Country Canada
 
Platforms (1)
GPL19057 Illumina NextSeq 500 (Mus musculus)
Samples (16)
GSM3932061 RNA-seq wildtype replicate 1 [TA RNA-seq]
GSM3932062 RNA-seq wildtype replicate 2 [TA RNA-seq]
GSM3932063 RNA-seq wildtype replicate 3 [TA RNA-seq]
This SubSeries is part of SuperSeries:
GSE110038 Hic1 defines quiescent mesenchymal progenitor subpopulations with distinct functions and fates in skeletal muscle regeneration
Relations
BioProject PRJNA553290
SRA SRP213792

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE133995_Supplemental_Table_3_RNA-seq_18m_Hic1_cKO_whole_TA_muscle_gene_expression.xlsx 3.6 Mb (ftp)(http) XLSX
SRA Run SelectorHelp
Raw data are available in SRA
Processed data are available on Series record

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