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Series GSE133509 Query DataSets for GSE133509
Status Public on Dec 10, 2019
Title Cancer avatars derived from genetically engineered pluripotent stem cells allow for longitudinal assessment of tumor development
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Many current cellular models aimed to elucidate cancer biology do not recapitulate pathobiology including tumor heterogeneity, an inherent feature of cancer that underlies treatment resistance. Here we introduce a new cancer modeling paradigm using genetically engineered human pluripotent stem cells (hiPSCs) that capture authentic cancer pathobiology. Orthotopic engraftment of the neural progenitor cells derived from hiPSCs introduced with tumor-associated genetic driver mutations revealed by The Cancer Genome Atlas project for glioblastoma (GBM) results in formation of brain tumors. As observed in GBM patient samples, these models harbor inter-tumor heterogeneity resembling different GBM molecular subtypes, and intra-tumor heterogeneity. Further, re-engraftment of these tumor cells generate tumors with features characteristic of patient samples and present mutation-dependent patterns of tumor evolution. Thus, these cancer avatar models provide a platform for a comprehensive longitudinal assessment of human tumor development as governed by molecular subtype mutations.
Overall design Analyses on inter- and intra-tumor heterogeneity of different glioblastoma derived from differentially engineered isogenic human induced pluripotent stem cells.
Contributor(s) Koga T, Chaim IA, Benitez JA, Markmiller S, Parisian AD, Turner KM, Hessenauer FM, D’Antonio M, Nguyen ND, Saberi S, Ma J, Miki S, Boyer AD, Ravits J, Frazer KA, Bafna V, Chen CC, Mischel PS, Yeo GW, Furnari FB
Citation(s) 31992716
Submission date Jun 28, 2019
Last update date Jul 14, 2020
Contact name Gene Yeo
Organization name UCSD
Street address 2880 Torrey Pines Scenic Dr. Room 3805/Yeo Lab
City La Jolla
State/province CA
ZIP/Postal code 92037
Country USA
Platforms (1)
GPL24676 Illumina NovaSeq 6000 (Homo sapiens)
Samples (14)
GSM3910556 P-S1
GSM3910557 P-T2.1
GSM3910558 P-T2.2
BioProject PRJNA551658
SRA SRP212301

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Supplementary file Size Download File type/resource
GSE133509_RAW.tar 248.0 Mb (http)(custom) TAR (of H5, HTML)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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