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Series GSE133399 Query DataSets for GSE133399
Status Public on Jun 30, 2020
Title CD103hi lung-resident regulatory T cells constrain the fibrotic responses induced by CD103low tissue-resident pathogenic CD4 T cells
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Genome binding/occupancy profiling by high throughput sequencing
Summary Tissue-resident memory T (TRM) cells are crucial mediators of adaptive immunity in non-lymphoid tissues. However, the functional heterogeneity and pathogenic roles of CD4+ TRM cells that reside within chronic inflammatory lesions remain unknown. We found that CD69hiCD103low CD4+ TRM cells produced effector cytokines and promoted the inflammation and fibrotic responses induced by chronic exposure to Aspergillus fumigatus. Simultaneously, immunosuppressive CD69hiCD103hiFoxp3+ CD4+ regulatory T (Treg) cells were induced and constrained the ability of pathogenic CD103low TRM cells to cause fibrosis. Thus, lung tissue-resident CD4+ T cells play crucial roles in the pathology of chronic lung inflammation, and CD103 expression defines pathogenic effector and immunosuppressive tissue-resident cell subpopulations in the inflamed lung.
 
Overall design T cells in lung treated with Aspergillus antigen are assessed by RNA-seq and ATAC-Seq.
 
Contributor(s) Ichikawa T, Hirahara K, Kokubo K, Kiuchi M, Aoki A, Morimoto Y, Kumagai J, Onodera A, Mato N, Tumes DJ, Goto Y, Hagiwara K, Inagaki Y, Sparwasser T, Tobe K, Nakayama T
Citation(s) 31591568
Submission date Jun 27, 2019
Last update date Oct 04, 2020
Contact name Kota Kokubo
E-mail(s) kt_kkb@yahoo.co.jp
Phone 9072003143
Organization name Chiba University
Department Department of Immunology
Street address Yachiyodai-minami 1-10-12
City Yachiyo-City
State/province Chiba
ZIP/Postal code 2760033
Country Japan
 
Platforms (1)
GPL18480 Illumina HiSeq 1500 (Mus musculus)
Samples (28)
GSM3908171 Fig2_CD44low_rep1
GSM3908172 Fig2_CD44hi_CD69low_rep1
GSM3908173 Fig2_CD44hi_CD69hi_CD103low_rep1
Relations
BioProject PRJNA551397
SRA SRP212167

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE133399_Fig2_FPKM.csv.gz 662.1 Kb (ftp)(http) CSV
GSE133399_Fig4_FPKM.csv.gz 865.6 Kb (ftp)(http) CSV
GSE133399_RAW.tar 662.4 Mb (http)(custom) TAR (of BIGWIG)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data are available on Series record
Processed data provided as supplementary file

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