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Series GSE133059 Query DataSets for GSE133059
Status Public on Oct 07, 2019
Title miRNA expression data from a cohort of Chilean Ulcerative Colitis human intestinal samples
Platform organism synthetic construct
Sample organism Homo sapiens
Experiment type Non-coding RNA profiling by array
Summary MicroRNAs have been associated with the pathogenesis of intestinal diseases such as colon cancer and are deregulated in the inflammatory environment of intestinal mucosa in UC patients. The effects of microRNAs on immunological factors have been described before, however, there is no evidence that they have an effect on alarmins that impact on the pathophysiology of UC. Our goal is to identify deregulated miRNAs to be paired with potential target mRNAs.
We used microarrays to compare inflamed and non inflamed mucosa from chilean ulcerative colitis patients
Overall design Inflamed and non inflamed human Intestinal biopsies were obtained in colonoscopy from Ulcerative Colitis patients and total RNA were extracted and hybridized using Affymetrix Eukaryotic Target Hybridization Controls protocol. MicroRNAs were extracted and then hybridized with Affymetrix MicroRNA microarray was accomplished using the Affymetrix GeneChipTM Version 4 microRNA arrays following the Affymetrix hybridization protocols (ThermoFisher Scientific Santa Clara, CA).
Contributor(s) Dubois-Camacho K, Cidlowski J, Díaz-Jimenez D
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Submission date Jun 20, 2019
Last update date Oct 09, 2019
Contact name NIEHS Microarray Core
Organization name NIEHS
Department DIR
Lab Microarray Core
Street address 111 T.W. Alexander Drive
City RTP
State/province NC
ZIP/Postal code 27709
Country USA
Platforms (1)
GPL19117 [miRNA-4] Affymetrix Multispecies miRNA-4 Array
Samples (16)
GSM3899195 Inflamed mucosa from UC patient 1
GSM3899196 Non inflamed mucosa from UC patient 1
GSM3899197 Inflamed mucosa from UC patient 2
This SubSeries is part of SuperSeries:
GSE133061 Gene and miRNA expression data from a cohort of Chilean Ulcerative Colitis human intestinal samples
BioProject PRJNA549860

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Supplementary file Size Download File type/resource
GSE133059_RAW.tar 16.4 Mb (http)(custom) TAR (of CEL, CHP)
Processed data provided as supplementary file

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