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Series GSE132884 Query DataSets for GSE132884
Status Public on Nov 01, 2021
Title Single-cell RNA-seq analysis reveals two specific endothelial cells promote fracture healing
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Recent studies have identified a bone vessel subtype of CD31hi endomucinhi (CD31hiEMCNhi) endothelium that positively promotes bone formation. However, it remains unknown how CD31hiEMCNhi endothelium participate in the healing of fractures. Here we find that CD31hiEMCNhi endothelial cells increase significantly during fracture healing by single-cell profiling. Furthermore, CD31hiEMCNhi endothelial cells can balance membrane and cartilage osteogenesis in this progress. Moreover, two different types of CD31hiEMCNhi endothelial cells were found in this progress, One of these endothelial cells tends to deliver molecules that induce mesenchymal stem cells differentiate into osteoblast. The other one tends to deliver inflammatory factors associated with osteoclasts. Thus, our study indicates that two specific endothelial cells promote fracture healing and may represent a potential treatment for promoting fracture healing.
Overall design scRNA profiles of fracture at different stage(control group, third day, 7th day, 14th day)
Contributor(s) Wang R, Tang H
Citation(s) 34819916
Submission date Jun 18, 2019
Last update date Dec 07, 2021
Contact name Renkai Wang
Organization name changhai hospital
Street address 168 Changhai Road,
City shanghai
ZIP/Postal code 200433
Country China
Platforms (1)
GPL21273 HiSeq X Ten (Mus musculus)
Samples (4)
GSM3895612 control group
GSM3895613 third day
GSM3895614 seventh day
BioProject PRJNA549397
SRA SRP201715

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Supplementary file Size Download File type/resource
GSE132884_AllNormalizedCounts.txt.gz 117.2 Mb (ftp)(http) TXT
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Raw data are available in SRA
Processed data are available on Series record

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