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Series GSE132682 Query DataSets for GSE132682
Status Public on Dec 29, 2021
Title Loss of ATF4 leads to functional aging-like attrition of adult hematopoietic stem cells [RNA-seq]
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary We collected significant amount of phenotypic and mechanistic data from a ATF4 knockout mouse model and demonstrated that HSC defects with an aging-like phenotype (expanded pool of phenotypical HSCs, decreased number of functional HSCs, impaired repopulating and self-renewal capacities of HSCs and myeloid bias) occurred in the ATF4 KO mice, suggesting that not only ATF4 indeed represents a pivotal factor for adult HSC function but also we had successfully constructed an ideal and attractive model to study aging and aging-related disease.
Overall design This dataset contains RNA-seq experiments of long-term HSCs isolated from ATF4WT or ATF4 CKO mice.
Contributor(s) Sun Y, Li M
Citation(s) 34936448
Submission date Jun 13, 2019
Last update date Dec 29, 2021
Contact name Yan Sun
Organization name Sun Yat-sen University
Street address Zhong shan 2nd Road, Building 74
City Guangzhou
State/province Guangdong
ZIP/Postal code 510080
Country China
Platforms (1)
GPL24247 Illumina NovaSeq 6000 (Mus musculus)
Samples (4)
GSM5595880 LT_HSC_ATF4-WT1
GSM5595881 LT_HSC_ATF4-WT2
GSM5595882 LT_HSC_ATF4 KO1
This SubSeries is part of SuperSeries:
GSE132683 Loss of ATF4 leads to functional aging-like attrition of adult hematopoietic stem cells
BioProject PRJNA548749
SRA SRP201328

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE132682_expr_ATF4.csv.gz 69.0 Kb (ftp)(http) CSV
SRA Run SelectorHelp
Raw data are available in SRA
Processed data are available on Series record

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