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| Status |
Public on Dec 29, 2021 |
| Title |
Loss of ATF4 leads to functional aging-like attrition of adult hematopoietic stem cells [RNA-seq] |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We collected significant amount of phenotypic and mechanistic data from a ATF4 knockout mouse model and demonstrated that HSC defects with an aging-like phenotype (expanded pool of phenotypical HSCs, decreased number of functional HSCs, impaired repopulating and self-renewal capacities of HSCs and myeloid bias) occurred in the ATF4 KO mice, suggesting that not only ATF4 indeed represents a pivotal factor for adult HSC function but also we had successfully constructed an ideal and attractive model to study aging and aging-related disease.
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| Overall design |
This dataset contains RNA-seq experiments of long-term HSCs isolated from ATF4WT or ATF4 CKO mice.
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| |
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| Contributor(s) |
Sun Y, Li M |
| Citation(s) |
34936448 |
| Submission date |
Jun 13, 2019 |
| Last update date |
Dec 29, 2021 |
| Contact name |
Yan Sun |
| E-mail(s) |
suny69@mail.sysu.edu.cn
|
| Organization name |
Sun Yat-sen University
|
| Street address |
Zhong shan 2nd Road, Building 74
|
| City |
Guangzhou |
| State/province |
Guangdong |
| ZIP/Postal code |
510080 |
| Country |
China |
| |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (4)
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| This SubSeries is part of SuperSeries: |
| GSE132683 |
Loss of ATF4 leads to functional aging-like attrition of adult hematopoietic stem cells |
|
| Relations |
| BioProject |
PRJNA548749 |
| SRA |
SRP201328 |
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