|
| Status |
Public on Mar 16, 2023 |
| Title |
Epigenetic misactivation of a distal developmental enhancer drives SOX2 overexpression in multiple cancer subtypes |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
We have investigated a distal regulatory region that drives SOX2 overexpression in multiple cancer subtypes
|
| |
|
| Overall design |
WT and homozygous enhancer-deleted (dEnh) cells were submitted for ribo-depelted total RNA-seq and ATAC-seq in three replicates each.
|
| Web link |
https://doi.org/10.1101/2023.03.14.532258
|
| |
|
| Contributor(s) |
Abatti LE, Mitchell JA |
| Citation missing |
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| Submission date |
Jun 06, 2019 |
| Last update date |
Mar 19, 2023 |
| Contact name |
Jennifer Mitchell |
| E-mail(s) |
ja.mitchell@utoronto.ca
|
| Phone |
4169786711
|
| Organization name |
University of Toronto
|
| Department |
Cell and Systems Biology
|
| Street address |
25 Harbord Street
|
| City |
Toronto |
| State/province |
Ontario |
| ZIP/Postal code |
M5S 3G5 |
| Country |
Canada |
| |
|
| Platforms (2) |
| GPL16791 |
Illumina HiSeq 2500 (Homo sapiens) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
| Samples (12)
|
|
| Relations |
| BioProject |
PRJNA547640 |
| SRA |
SRP200701 |
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