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Series GSE132108 Query DataSets for GSE132108
Status Public on Jun 04, 2019
Title Motor dysfunction and neurodegeneration in a C9orf72 mouse line expressing poly-PR
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary GFP-PR28 homozygous mice show decreased survival time, while the heterozygous mice show motor imbalance, decreased brain weight, loss of Purkinje cells and lower motor neurons, and inflammation in the cerebellum and spinal cord. Transcriptional analysis shows that in the cerebellum, GFP-PR28 heterozygous mice show differential expression of genes related to synaptic transmission.
Overall design The mRNA profiles of cerebellum, cortex and spinal cord of control and heterozygous mice were generated by RNA sequencing, in triplicate, using Illumina HiSeq X Ten
Contributor(s) Hao Z, Liu L, Tao Z, Wang R, Ren H, Sun H, Lin Z, Zhang Z, Mu C, Zhou J, Wang G
Citation(s) 31266945
Submission date Jun 03, 2019
Last update date Jul 16, 2019
Contact name Zongbing Hao
Organization name Soochow University
Street address 199 Ren-ai Road
City Suzhou
ZIP/Postal code 215123
Country China
Platforms (1)
GPL21273 HiSeq X Ten (Mus musculus)
Samples (24)
GSM3844053 1_2m_WT
GSM3844054 3_2m_WT
GSM3844055 5_2m_WT
BioProject PRJNA545960
SRA SRP200201

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Supplementary file Size Download File type/resource
GSE132108_2_and_5_months_cerebellum_raw_counts.txt.gz 768.0 Kb (ftp)(http) TXT
GSE132108_6_months_cortex_and_spinal_cord_raw_counts.txt.gz 796.8 Kb (ftp)(http) TXT
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Raw data are available in SRA
Processed data are available on Series record

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