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Series GSE131710 Query DataSets for GSE131710
Status Public on May 05, 2021
Title ChIP-seq analysis of BRD4, MED1 and P65 in SCC1 cells after JQ1 treatment
Organism Homo sapiens
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary To explore genome-wide alteration of BRD4, MED1, p65 and H3K27Ac during BET inhibition, we performed chromatin immunoprecipitation sequencing (ChIP-seq) of SCC1 cells to examine genome-wide recruitment of the MED1, BRD4, p65 and H3K27ac following JQ1 treatment. BET inhibition by JQ1 led to dramatically loss of the recruitment of MED1, BRD4 and p65 at a cohort of key oncogenes associate with tumorigenesis and metastasis. Suggesting BET inhibition is effective strategy to suppress the tumorigenesis and metastasis of head and neck squamous cell carcinoma.
Overall design Examination of ChIP-seq of HNSCC cells treated with JQ1.
Contributor(s) Li J
Citation(s) 34172737
Submission date May 23, 2019
Last update date Jul 14, 2021
Contact name Jiong Li
Phone 3105617186
Organization name VCU
Street address 800 E Leigh Street, suite 212
City Richmond
State/province Virginia
ZIP/Postal code 23298
Country USA
Platforms (1)
GPL21290 Illumina HiSeq 3000 (Homo sapiens)
Samples (10)
GSM3814478 Input control
GSM3814479 Input JQ1 treatment
GSM3814480 MED1 control
BioProject PRJNA544484
SRA SRP199338

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Supplementary file Size Download File type/resource
GSE131710.tar.gz 363.7 Mb (ftp)(http) TAR
GSE131710_RAW.tar 1.0 Gb (http)(custom) TAR (of BW)
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Raw data are available in SRA
Processed data provided as supplementary file
Processed data are available on Series record

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