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| Status |
Public on May 05, 2021 |
| Title |
ChIP-seq analysis of BRD4, MED1 and P65 in SCC1 cells after JQ1 treatment |
| Organism |
Homo sapiens |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
To explore genome-wide alteration of BRD4, MED1, p65 and H3K27Ac during BET inhibition, we performed chromatin immunoprecipitation sequencing (ChIP-seq) of SCC1 cells to examine genome-wide recruitment of the MED1, BRD4, p65 and H3K27ac following JQ1 treatment. BET inhibition by JQ1 led to dramatically loss of the recruitment of MED1, BRD4 and p65 at a cohort of key oncogenes associate with tumorigenesis and metastasis. Suggesting BET inhibition is effective strategy to suppress the tumorigenesis and metastasis of head and neck squamous cell carcinoma.
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| |
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| Overall design |
Examination of ChIP-seq of HNSCC cells treated with JQ1.
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| |
|
| Contributor(s) |
Li J |
| Citation(s) |
34172737 |
| |
| Submission date |
May 23, 2019 |
| Last update date |
Jul 14, 2021 |
| Contact name |
Jiong Li |
| E-mail(s) |
jli29@vcu.edu
|
| Phone |
3105617186
|
| Organization name |
VCU
|
| Street address |
800 E Leigh Street, suite 212
|
| City |
Richmond |
| State/province |
Virginia |
| ZIP/Postal code |
23298 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL21290 |
Illumina HiSeq 3000 (Homo sapiens) |
|
| Samples (10)
|
|
| Relations |
| BioProject |
PRJNA544484 |
| SRA |
SRP199338 |
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