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Series GSE131664 Query DataSets for GSE131664
Status Public on May 23, 2020
Title Identifying new signaling mediators responsible for Mesothelin (MSLN) intraperitoneal (IP) tumor growth phenotype
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Identification of new targets involved in MSLN signaling by comparing mRNA expression patterns in MSLN WT and KO in both cells grown in culture and in IP tumor tissues using RNA deep sequencing
Overall design Compare and contrast tanscriptome of MSLN WT and KO cells grown in culture and IP tumors tissues using RNAseq
The parent KLM1 cell line was crispr edited to make the following cell lines Mock, KO#1 and KO#2. The KO lackMesothelin. These same human-derived cell lines were put into nude mice to form intraperitoneal tumors.
Contributor(s) Avula LR, Rudloff M, Alewine C, Chen X
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Submission date May 22, 2019
Last update date May 23, 2020
Contact name Jack Chen
Organization name NIH
Street address SAIC-Frederick Miller Dr
City Frederick
State/province MD
ZIP/Postal code 21702
Country USA
Platforms (1)
GPL21290 Illumina HiSeq 3000 (Homo sapiens)
Samples (25)
GSM3801009 KLM740
GSM3801010 KLM734
GSM3801011 KLM736
BioProject PRJNA544323
SRA SRP199242

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Supplementary file Size Download File type/resource
GSE131664_RawCount_genes_unfiltered1.txt.gz 1.1 Mb (ftp)(http) TXT
GSE131664_RawCount_genes_unfiltered2.txt.gz 806.6 Kb (ftp)(http) TXT
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Processed data are available on Series record

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