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Series GSE131518 Query DataSets for GSE131518
Status Public on Oct 31, 2019
Title Analysis of gene expression in CNOT2-depleted A549 lung cancer cells
Organism Homo sapiens
Experiment type Expression profiling by array
Summary CNOT2 depletion partially decreased number of colony in colony forming assay and cell number in proliferation assay for NSCLC cells. Co-treatment with TRAIL and depletion of CNOT2 dramatically declined survival rate and increased apoptosis compared with TRAIL only in TRAIL resistant NSCLC cells. So, to find major signaling molecules in CNOT2 depleted condition of A549 cells, gene expression analysis was designed.
Overall design NSCLC cells were plated at 60% confluency in 60mm dish 24 hours before transfection. shRNAs were designed against specific target sequence of human CNOT2 mRNAs.
Contributor(s) Yun M, Kim S
Citation(s) 31894259
Submission date May 20, 2019
Last update date Feb 10, 2020
Contact name Miyong Yun
Phone 82-10-9269-3086
Organization name Sejong University
Department Bioindustry and bioresource engineering
Street address 209, Neungdong-ro, Gwangjin-gu
City Seoul
ZIP/Postal code 05006
Country South Korea
Platforms (1)
GPL17077 Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Probe Name version)
Samples (2)
GSM3783667 A549-sh_con
GSM3783668 A549-sh_CNOT2
BioProject PRJNA543868

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE131518_RAW.tar 6.1 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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