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| Status |
Public on May 18, 2019 |
| Title |
The effects of chemokines CCL2/7 on MDA-MB-231-FOXC1 cells |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Our preliminary studies performed in vitro show that MDA-MB-231-FOXC1 cell, which were used to mimic the lung-colonizing triple-negative breast cancer cells, was an indispensable component for the induction of migration and tube formation of lung endothelial cells. Moreover, our results further show that mouse lung fibroblast-derived chemokines CCL2/7 act on MDA-MB-231-FOXC1 cells, which mediates the migration and tube formation of lung endothelial cells in vitro. To understand the signaling pathways activated by CCL2/7 in MDA-MB-231-FOXC1 cells, we performed RNA-Seq assay.
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| Overall design |
MDA-MB-231-FOXC1 cells were treated with recombinant mouse Ccl2 (10 nM)/7 (50 nM) for 6 hours.
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| Contributor(s) |
Han B, Deng N, Cui X |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
May 17, 2019 |
| Last update date |
May 20, 2019 |
| Contact name |
Xiaojiang Cui |
| E-mail(s) |
bowen.gao@cshs.org
|
| Phone |
3104237437
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| Organization name |
Cedars Sinai Medical Center
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| Department |
Surgery Dept
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| Lab |
Breast Cancer Research Lab
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| Street address |
3884 Fredonia Dr#F
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| City |
Los Angeles |
| State/province |
CA |
| ZIP/Postal code |
90068 |
| Country |
USA |
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| Platforms (1) |
| GPL21290 |
Illumina HiSeq 3000 (Homo sapiens) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA543438 |
| SRA |
SRP198746 |
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