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Series GSE131383 Query DataSets for GSE131383
Status Public on May 18, 2019
Title The effects of chemokines CCL2/7 on MDA-MB-231-FOXC1 cells
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Our preliminary studies performed in vitro show that MDA-MB-231-FOXC1 cell, which were used to mimic the lung-colonizing triple-negative breast cancer cells, was an indispensable component for the induction of migration and tube formation of lung endothelial cells. Moreover, our results further show that mouse lung fibroblast-derived chemokines CCL2/7 act on MDA-MB-231-FOXC1 cells, which mediates the migration and tube formation of lung endothelial cells in vitro. To understand the signaling pathways activated by CCL2/7 in MDA-MB-231-FOXC1 cells, we performed RNA-Seq assay.
Overall design MDA-MB-231-FOXC1 cells were treated with recombinant mouse Ccl2 (10 nM)/7 (50 nM) for 6 hours.
Contributor(s) Han B, Deng N, Cui X
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Submission date May 17, 2019
Last update date May 20, 2019
Contact name Xiaojiang Cui
Phone 3104237437
Organization name Cedars Sinai Medical Center
Department Surgery Dept
Lab Breast Cancer Research Lab
Street address 3884 Fredonia Dr#F
City Los Angeles
State/province CA
ZIP/Postal code 90068
Country USA
Platforms (1)
GPL21290 Illumina HiSeq 3000 (Homo sapiens)
Samples (6)
GSM3772942 Cntl1: Control-1_S1
GSM3772943 Cntl2: Control-1_S2
GSM3772944 Cntl3: Control-1_S3
BioProject PRJNA543438
SRA SRP198746

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE131383_Processed_data.xlsx 1.9 Mb (ftp)(http) XLSX
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Raw data are available in SRA
Processed data are available on Series record

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