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Series GSE131355 Query DataSets for GSE131355
Status Public on May 17, 2019
Title Transcriptome sequencing analysis of Mesenchymal Stem Cells derived from the Human Placenta and Umbilical Cord
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Based on transcriptome sequencing analysis, umbilical cord mesenchymal stem cells and placental mesenchymal stem cells share a total of 10529 common genes (called hpcCS consensus genes), which are umbilical cord-placental-consistent DEGs. The UC-MSC-specific region (referred to as the UC-specific gene) has most of the DEG (383 genes). The AM-MSC specific region (referred to as the AM specific gene) has 311 DEGs. The CM-MSC specific region (referred to as the CM specific gene) has 182 DEGs. The CV-MSC specific region (referred to as a CV-specific gene) has 169 DEGs. These results suggest that hMSCs from the umbilical cord and placenta have similar gene expression patterns, but have their own specific genes. The specific genes are not only involved in cell cycle, cell division, cell death, cell growth and development, transcriptional regulation, DNA repair, DNA. Replication plays an important role in chromosomal stability and is also involved in the movement of cellular or subcellular components, cellular communication and cell projection tissue, cytokine secretion and hormonal metabolism. The results of transcriptome sequencing analysis explain to some extent the differences in the biological characteristics of MSCs from different sources at the gene level.
Overall design We compared the transcriptional profiles of four different placenta-drived MSCs using RNA-sequencing (RNA-seq)
Contributor(s) Xiao Y, Feng C
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Submission date May 16, 2019
Last update date May 18, 2019
Contact name Yi Xiao
Phone 18826559096
Organization name Southern Medical University
Street address No. 253, Industrial Avenue, Haizhu District
City Guangzhou
ZIP/Postal code 510000
Country China
Platforms (1)
GPL24676 Illumina NovaSeq 6000 (Homo sapiens)
Samples (4)
GSM3771255 UC-MSC
GSM3771256 AM-MSC
GSM3771257 CM-MSC
BioProject PRJNA543326
SRA SRP198666

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Supplementary file Size Download File type/resource
GSE131355_RAW.tar 5.2 Mb (http)(custom) TAR (of XLS)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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