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Series GSE129771 Query DataSets for GSE129771
Status Public on Apr 14, 2019
Title Transcriptome profiling of mouse subcutaneous white adipose tissue treated with BML-260
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary To explore BML-260 how to increase thermogenesis, we examined the effect of BML-260 by direct in situ injection into the subcutaneous white adipose depot. Three days after a single injection, mice were dissected and subcutaneous adipose tissues were obtained for RNA extraction. we noticed that BML-260 treatment resulted in a very significant upregulation of genes involved in thermogenesis. And gene signatures of muscle cell differentiation, muscle structure development, regulation of muscle system process were among the most enriched GO terms. Our work provides evidences that BML-260 can also exert a JSP-1-independent effect in activating UCP1 and thermogenesis in adipocytes, and be potentially applied to treat obesity.
Overall design Four mice subcutaneous white adipose tissues from 8 mice: 4 mice were treated with BML-260, 4 mice were treated with vehicle.
Contributor(s) Ding Q, Feng Z, Wei Y, Zhang Y, Qiu Y, Liu X
Citation(s) 31281493
Submission date Apr 13, 2019
Last update date Jul 14, 2019
Contact name Zhuanghui Feng
Organization name Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences
Street address 320 Yueyang Road
City Shanghai
ZIP/Postal code 200031
Country China
Platforms (1)
GPL24247 Illumina NovaSeq 6000 (Mus musculus)
Samples (4)
GSM3721891 ctrlA
GSM3721892 ctrlB
GSM3721893 bmlA
BioProject PRJNA532721
SRA SRP192492

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Supplementary file Size Download File type/resource
GSE129771_DiffExp_G_Ctrl_vs_BML_ref.txt.gz 1.7 Mb (ftp)(http) TXT
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