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Series GSE129042 Query DataSets for GSE129042
Status Public on Apr 25, 2019
Title Identification of metabolically distinct adipocyte progenitor cells in human adipose tissues
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Adipocyte progenitor cells (APCs) provide the reservoir of regenerative cells to produce new adipocytes, although their identity in humans remains elusive. Using FACS analysis, gene expression profiling and metabolic and proteomic analyses, we identified three APCs subtypes in human white adipose tissues. The APC subtypes are molecularly distinct but possess similar proliferative and adipogenic capacities. Adipocytes derived from APCs with high CD34 expression exhibit exceedingly high rates of lipid flux compared with APCs with low or no CD34 expression, while adipocytes produced from CD34- APCs display beige-like adipocyte properties and a unique endocrine profile. APCs were more abundant in gluteofemoral compared with abdominal subcutaneous and omental adipose tissues, and the distribution of APC subtypes varies between depots and in patients with type 2 diabetes. These findings provide a mechanistic explanation for the heterogeneity of human white adipose tissue and a potential basis for dysregulated adipocyte function in type 2 diabetes.
Overall design Molecular, biochemical and clinical examination of three cell types wthin the stromal vascular fraction of human adipose tissue.
Contributor(s) Raajendiran A, Brien PO, Taylor RA, Rodeheffer MS, Burton PR, Watt MJ, Archer SK
Citation(s) 31042478
Submission date Mar 29, 2019
Last update date May 06, 2019
Contact name Stuart Kenneth Archer
Organization name Monash University
Department Monash Bioinformatics Platform
Street address 15 Innovation Walk, Monash University
City Clayton
State/province VIC
ZIP/Postal code 3800
Country Australia
Platforms (1)
GPL18460 Illumina HiSeq 1500 (Homo sapiens)
Samples (15)
GSM3692196 P1_Neg
GSM3692197 P1_Low
GSM3692198 P1_High
BioProject PRJNA529861
SRA SRP189867

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Supplementary file Size Download File type/resource
GSE129042_counts.txt.gz 389.6 Kb (ftp)(http) TXT
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