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Status |
Public on Jun 19, 2019 |
Title |
Comparing 3D genome organization in multiple species using Phylo-HMRF |
Organisms |
Gorilla gorilla; Pan paniscus; Pan troglodytes |
Experiment type |
Other
|
Summary |
We developed a continuous-trait probabilistic model to identify genome-wide evolutionary patterns of 3D genome structures based on multi-species Hi-C data. We applied the proposed method to analyzing cross-species Hi-C data from the same cell type in multiple primate species. The results showed that the proposed method enables discovery of distinct Hi-C contact frequency evolutionary patterns across species.
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Overall design |
Comparing Hi-C contact frequencies among multiple primate species
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Contributor(s) |
Yang Y, Zhang Y, Ren B, Dixon J, Ma J |
Citation(s) |
31229558 |
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Submission date |
Mar 25, 2019 |
Last update date |
Jul 03, 2019 |
Contact name |
Yang Yang |
E-mail(s) |
yy3@andrew.cmu.edu
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Organization name |
Carnegie Mellon University
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Department |
Computational Biology
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Street address |
5000 Forbes Ave
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City |
Pittsburgh |
State/province |
PA |
ZIP/Postal code |
15213 |
Country |
USA |
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Platforms (3) |
GPL19148 |
Illumina HiSeq 2500 (Pan troglodytes) |
GPL24148 |
Illumina HiSeq 2500 (Gorilla gorilla) |
GPL24149 |
Illumina HiSeq 2500 (Pan paniscus) |
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Samples (3) |
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Relations |
BioProject |
PRJNA528916 |
SRA |
SRP189342 |