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Series GSE128748 Query DataSets for GSE128748
Status Public on Mar 22, 2020
Title RNA-seq analysis of dolastatin 15 treatment in HCT116 cells
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Dolastatin 15 is a known tubulin binding agent and shows remarkable differential cytotoxicity against a panel of colorectal HCT116 isogenic cells. The compound causes anti-vascularization effect in human endothelial cells (HUVEC) in a dose dependent manner. Antiangiogenic effect was further validated in a zebrafish genetic model with activated HIF
Overall design Examination of Dolastatin 15 effect on HCT116 cells relative to solvent controls using two different concentrations of 20 nM and 100 nM at 16 and 24 hour time points
Contributor(s) Luesch H, Ratnayake R
Citation(s) 32237262
Submission date Mar 23, 2019
Last update date Jun 24, 2020
Contact name Tongjun Gu
Organization name The University of Florida
Department ICBR
Street address 2033 Mowry Road
City Gainesville
State/province FL
ZIP/Postal code 32610
Country USA
Platforms (1)
GPL21290 Illumina HiSeq 3000 (Homo sapiens)
Samples (12)
GSM3684373 Dolastatin 15; 20 nM treatment at 16H sample 1
GSM3684374 Dolastatin 15; 20 nM treatment at 16H sample 2
GSM3684375 Dolastatin 15; 100 nM treatment at 16H sample 1
BioProject PRJNA528759
SRA SRP189242

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Supplementary file Size Download File type/resource
GSE128748_gene_expr_fpkm.txt.gz 702.6 Kb (ftp)(http) TXT
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Raw data are available in SRA
Processed data are available on Series record

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