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| Status |
Public on Mar 15, 2022 |
| Title |
Single cell changes in postnatal P7 and in adult cardiac endothelium upon VEGF-B overexpression |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We have previously reported that mice expressing a cardiomyocyte-specific αMHC-VEGF-B transgene in the heart show a clear expansion of the coronary vasculature and cardiac hypertrophy, without significant changes in heart function. As a therapeutic way of administrating VEGF-B protective effects, we show that AAV-VEGF-B induces the proliferation of endothelial cells (EC). All the samples were analyzed using the Chromium Single-cell 3'RNA-sequencing system.
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| Overall design |
We analyzed in total 4 samples, aiming with all the samples at 3000 cells.
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| Contributor(s) |
Räsänen M, Alitalo K |
| Citation missing |
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| Submission date |
Mar 19, 2019 |
| Last update date |
Mar 17, 2022 |
| Contact name |
Markus Räsänen |
| Organization name |
Wihuri Research Insitute
|
| Street address |
Haartmaninkatu 8
|
| City |
Helsinki |
| ZIP/Postal code |
00290 |
| Country |
Finland |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (4)
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| Relations |
| BioProject |
PRJNA527960 |
| SRA |
SRP188808 |
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