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Series GSE128509 Query DataSets for GSE128509
Status Public on Mar 15, 2022
Title Single cell changes in postnatal P7 and in adult cardiac endothelium upon VEGF-B overexpression
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary We have previously reported that mice expressing a cardiomyocyte-specific αMHC-VEGF-B transgene in the heart show a clear expansion of the coronary vasculature and cardiac hypertrophy, without significant changes in heart function. As a therapeutic way of administrating VEGF-B protective effects, we show that AAV-VEGF-B induces the proliferation of endothelial cells (EC). All the samples were analyzed using the Chromium Single-cell 3'RNA-sequencing system.
Overall design We analyzed in total 4 samples, aiming with all the samples at 3000 cells.
Contributor(s) Räsänen M, Alitalo K
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Submission date Mar 19, 2019
Last update date Mar 17, 2022
Contact name Markus Räsänen
Organization name Wihuri Research Insitute
Street address Haartmaninkatu 8
City Helsinki
ZIP/Postal code 00290
Country Finland
Platforms (1)
GPL24247 Illumina NovaSeq 6000 (Mus musculus)
Samples (4)
GSM3678221 aMHC-Vegfb p7 TG
GSM3678222 aMHC-Vegfb p7 WT
GSM3678223 AAV9-Vegfb
BioProject PRJNA527960
SRA SRP188808

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE128509_RAW.tar 68.0 Mb (http)(custom) TAR (of MTX, TSV)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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