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Series GSE128492 Query DataSets for GSE128492
Status Public on Mar 18, 2020
Title Benzo[a]pyrene and dibenzo[def,p]chrysene in 3D primary human bronchial epithelial cells [miRNA-seq]
Organism Homo sapiens
Experiment type Non-coding RNA profiling by high throughput sequencing
Summary In this study, we assess potential differences in mechanism of action for two PAHs, benzo[a]pyrene (BAP) and dibenzo-[def,p]chrysene (DBC), in a primary human 3D bronchial epithelial culture (HBEC) model based on short-term biosignatures identified from global transcriptional profiling.
Overall design Fully differentiated bronchial epithelial cells (n=4 replicates) were treated with 500 µg/ml (19.80 nanomoles) benzo[a]pyrene (BAP), 10 µg/ml (0.35 nanomoles) dibenzo[def,p]chrysene (DBC) or acetone vehicle control for 48 hrs and isolated mRNA were sequenced on Illumina HiSeq 3000.
Contributor(s) Tilton SC
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Submission date Mar 18, 2019
Last update date Mar 21, 2020
Contact name Susan C. Tilton
Organization name Oregon State University
Department AG Envr & Molec Toxicology
Street address 1007 ALS Bldg
City Corvallis
State/province OR
ZIP/Postal code 97331
Country USA
Platforms (1)
GPL21290 Illumina HiSeq 3000 (Homo sapiens)
Samples (12)
GSM3677533 HBEC_VehCon_1 [miRNA-seq]
GSM3677534 HBEC_VehCon_2 [miRNA-seq]
GSM3677535 HBEC_VehCon_3 [miRNA-seq]
BioProject PRJNA527841
SRA SRP188759

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE128492_RAW.tar 220.0 Kb (http)(custom) TAR (of TXT)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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