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Series GSE126442 Query DataSets for GSE126442
Status Public on Feb 13, 2019
Title Gene expression analysis of a subcutaneous MV4;11 tumor treated with curaxin CBL0137.
Organisms Homo sapiens; Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary The aim of this experiment was to identify how CBL0137 decreased tumor growth in a subcutaneous MV4;11 xenograft model by investigating the gene expression changes induced upon treatment.
Overall design > 1 million MV4;11 cells were inoculated subcutaneously in the flank of NOD/SCID (NOD/SCID NOD.CB17-Prkdcscid/SzJ) mice. When tumors measured around 100 mm3, mice were treated with CBL0137 (70 mg/kg CBL0137 intravenously) on day 0 and day 8. Tumors were harvested 24h post last injection on day 8. Tumors were also harvested from untreated mice. Tumors were flash frozen in liquid nitrogen and RNA was isolated.
Contributor(s) Gurova KV, Neznanov N, Mayoh C, Somers K, Henderson MJ
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Submission date Feb 12, 2019
Last update date Feb 13, 2019
Contact name Michelle Haber
Organization name Children's Cancer Institute
Street address Lowy Cancer Research Centre, PO BOX 81
City Randwick
State/province NSW
ZIP/Postal code 2031
Country Australia
Platforms (1)
GPL22245 Illumina HiSeq 2500 (Homo sapiens; Mus musculus)
Samples (4)
GSM3601942 MV4;11 untreated replicate 1
GSM3601943 MV4;11 untreated replicate 2
GSM3601944 MV4;11 70 mg/kg CBL0137 treated replicate 1
BioProject PRJNA521944
SRA SRP185693

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Supplementary file Size Download File type/resource
GSE126442_GeneExpression_TPM_Counts_mv411_treated_untreated_human.txt.gz 231.9 Kb (ftp)(http) TXT
GSE126442_GeneExpression_TPM_Counts_mv411_treated_untreated_mouse.txt.gz 216.9 Kb (ftp)(http) TXT
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