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Series GSE126066 Query DataSets for GSE126066
Status Public on Nov 05, 2019
Title Nanoparticle-coupled topical methotrexate effectively inhibits inflammation and induces re-modeling in pre-clinical psoriasis
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary This project explores the efficacy of a novel skin-permeable MTX formulation, on murine and human xenotransplant models of psoriasis. Phenotypical and histological examinations of psoriatic tissue in these models have shown that the novel MTX can significantly suppress the inflammation. In order to understand the mechanistics of the new drug transcriptome of different treatment regimens (MTX-based, corticosteroid-based, and Vaseline control) will be compared to assess the pathological state of the skin.
Overall design Transcriptomic changes of human skin on a xenotransplant model upon topical therapy was compared to psoriatic and normal-appearing skin from psoriasis patients
Contributor(s) Oezcan A, Kolios AA
Citation(s) 31678057
Submission date Feb 04, 2019
Last update date Nov 05, 2019
Contact name Ge Tan
Organization name University of Zurich
Department Functional Genomics Center Zurich
Street address Winterthurerstrasse 190
City Zurich
ZIP/Postal code 8057
Country Switzerland
Platforms (1)
GPL24676 Illumina NovaSeq 6000 (Homo sapiens)
Samples (13)
GSM3590062 Daiv1
GSM3590063 Daiv2
GSM3590064 LE1
BioProject PRJNA520906
SRA SRP183510

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE126066_Count_QC-raw-count.txt.gz 720.9 Kb (ftp)(http) TXT
SRA Run SelectorHelp
Raw data are available in SRA
Processed data are available on Series record

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