|
| Status |
Public on Nov 05, 2019 |
| Title |
Nanoparticle-coupled topical methotrexate effectively inhibits inflammation and induces re-modeling in pre-clinical psoriasis |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
This project explores the efficacy of a novel skin-permeable MTX formulation, on murine and human xenotransplant models of psoriasis. Phenotypical and histological examinations of psoriatic tissue in these models have shown that the novel MTX can significantly suppress the inflammation. In order to understand the mechanistics of the new drug transcriptome of different treatment regimens (MTX-based, corticosteroid-based, and Vaseline control) will be compared to assess the pathological state of the skin.
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| |
|
| Overall design |
Transcriptomic changes of human skin on a xenotransplant model upon topical therapy was compared to psoriatic and normal-appearing skin from psoriasis patients
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| |
|
| Contributor(s) |
Oezcan A, Kolios AA |
| Citation(s) |
31678057 |
| Submission date |
Feb 04, 2019 |
| Last update date |
Nov 05, 2019 |
| Contact name |
Ge Tan |
| E-mail(s) |
ge_tan@outlook.com
|
| Organization name |
University of Zurich
|
| Department |
Functional Genomics Center Zurich
|
| Street address |
Winterthurerstrasse 190
|
| City |
Zurich |
| ZIP/Postal code |
8057 |
| Country |
Switzerland |
| |
|
| Platforms (1) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
| Samples (13)
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|
| Relations |
| BioProject |
PRJNA520906 |
| SRA |
SRP183510 |
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