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Series GSE125788 Query DataSets for GSE125788
Status Public on May 17, 2021
Title Transcription profiling of IL-4-expressing CD4 T cells in the lung and lung-draining lymph nodes
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Using single cell RNA-sequencing and whole-genome targeted transcription profiling, this study reveals that helminth infection causes the expansion of distinct but clonally related IL-4-competent CD4+ T cells in the lung and lung-draining lymphoid tissues providing insight into tissue-specific mechanisms of type-2 cytokine regulation and the lineage commitment of T-helper 2 (Th2) and T follicular helper (Tfh) cells.
Overall design Genome-wide targeted sequencing to profile transcription of 4 distinct CD4+ T cells in lymphoid and nonlymphoid tissues
Contributor(s) Reinhardt RL, Seibold MA, Dyjack N
Citation(s) 34106992
NIH grant(s)
Grant ID Grant title Affiliation Name
R01 AI119004 The Role of BATF in Allergic Inflammation and Anti-Helminth Immunity NATIONAL JEWISH HEALTH Richard Lee Reinhardt
R01 AI156901 The Origin and Role of Pulmonary ILC2 Subsets in Anti-Helminth Immunity NATIONAL JEWISH HEALTH Richard Lee Reinhardt
Submission date Jan 28, 2019
Last update date Aug 16, 2021
Contact name Richard Lee Reinhardt
Organization name National Jewish Health
Department Biomedical Research
Lab Reinhardt
Street address 1400 Jackson Street, K817A
City Denver
State/province Colorado
ZIP/Postal code 80206
Country USA
Platforms (2)
GPL24247 Illumina NovaSeq 6000 (Mus musculus)
GPL25723 Ion Torrent S5 (Mus musculus)
Samples (29)
GSM3581882 IL4-positive lymph node
GSM3581883 IL4-negative lymph node
GSM3581884 IL-4-positive Lung
BioProject PRJNA517508
SRA SRP182726

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE125788_10x_rawData.txt.gz 5.5 Mb (ftp)(http) TXT
GSE125788_10x_scaledData.txt.gz 283.9 Mb (ftp)(http) TXT
GSE125788_124.18-04-18.S5XL-00648.bcmatrix.txt.gz 381.8 Kb (ftp)(http) TXT
GSE125788_139.19-09-18.S5XL-00648.bcmatrix.txt.gz 659.5 Kb (ftp)(http) TXT
GSE125788_144.21-09-18.S5XL-00648.bcmatrix.txt.gz 671.5 Kb (ftp)(http) TXT
GSE125788_145.21-09-18.S5XL-00648.bcmatrix.txt.gz 666.6 Kb (ftp)(http) TXT
GSE125788_RawCount_Matrix.txt.gz 706.5 Kb (ftp)(http) TXT
GSE125788_countNorm_Matrix.txt.gz 2.6 Mb (ftp)(http) TXT
GSE125788_vstNorm_Matrix.txt.gz 2.7 Mb (ftp)(http) TXT
SRA Run SelectorHelp
Raw data are available in SRA
Processed data are available on Series record

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