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Series GSE125742 Query DataSets for GSE125742
Status Public on Mar 29, 2019
Title Nano genome altas (NGA) of body wide tissue specific responses
Organisms Homo sapiens; Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Purpose: In order to detect the unpredictable risks of the cumulative nanoparticles infiltrated everywhere in the whole body after systematic administration

Methods: By using RNA-seq, we systematically studied the transcriptomic response of multi-organs from mice and tissue specific (stem) cells to the hydroxyapatite (HA) nano-delivery system.

Results: We show that HA could differentially influence gene expression, immune response, cell proliferation, stress, apoptosis, metabolic, ion transport activity, cell signaling and epigenetic activity across tissues and tissue specific (stem) cells.
Overall design We collected mouse tissues of heart, liver, spleen, kidney, skeletal muscle, peripheral blood mononuclear cells (PBMC) as well as tissue specific (stem) cells of mouse skeletal muscle derived stem cells (MUSC), Human bone marrow derived stem cells (hBMSC), Human primary umbilical vein endothelial cell lines (HUVEC) for RNA-seq after treated with the two groups (PBS control and HA solution) for 24hours, respectively.
Contributor(s) Wu B, Zou X, Ouyang H
Citation(s) 30903824
Submission date Jan 28, 2019
Last update date Mar 29, 2019
Contact name Bingbing Wu
Phone +86-571-13735548673
Organization name Zhejiang University
Department School of Medcine
Lab Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cell and Regenerative Medicine
Street address 866 Yuhangtang Rd
City HangZhou
State/province Zhejiang
ZIP/Postal code 310058
Country China
Platforms (2)
GPL20795 HiSeq X Ten (Homo sapiens)
GPL21273 HiSeq X Ten (Mus musculus)
Samples (58)
GSM3581283 WBJPE170996013
GSM3581284 WBJPE170996017
GSM3581285 WBJPE170996018
BioProject PRJNA517433
SRA SRP182662

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE125742_human-counts-5-23-ID.xlsx 3.4 Mb (ftp)(http) XLSX
GSE125742_mice-counts-5-23-ID.xlsx 5.0 Mb (ftp)(http) XLSX
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Raw data are available in SRA
Processed data are available on Series record

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