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Series GSE125527 Query DataSets for GSE125527
Status Public on Jul 16, 2020
Title Single-Cell Analyses Elucidate the Cellular and Molecular Landscape of Ulcerative Colitis
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Inflammatory bowel disease (IBD) encompasses a spectrum of complex intestinal disorders characterized by dysregulated host innate and adaptive immune responses to gut microbiota in genetically susceptible hosts. We generated an integrated single-cell (scRNA-seq, scTCR-seq, and scBCR-seq) resource dataset that revealed key cellular components and cell states of the gastrointestinal mucosal and peripheral immune systems in health and ulcerative colitis (UC).
Overall design Single-cell RNA-seq and BCR/TCR repertoire analyses of immune cell from 15 patients
Contributor(s) Chang J, He Z
Citation(s) 32826341
Submission date Jan 23, 2019
Last update date Sep 14, 2020
Contact name John Chang
Organization name UCSD
Department School of Medicine
Lab Chang lab
Street address 9500 Gilman Drive
City La Jolla
State/province CA
ZIP/Postal code 92093
Country USA
Platforms (2)
GPL20301 Illumina HiSeq 4000 (Homo sapiens)
GPL24676 Illumina NovaSeq 6000 (Homo sapiens)
Samples (103)
GSM3576396 C9_R_10x_scRNA
GSM3576397 C12_R_10x_scRNA
GSM3576398 C16_R_10x_scRNA
BioProject PRJNA516681
SRA SRP181666

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE125527_Bcell_cluster.csv.gz 85.6 Kb (ftp)(http) CSV
GSE125527_RAW.tar 120.5 Mb (http)(custom) TAR (of TSV)
GSE125527_Tcell_cluster.csv.gz 224.4 Kb (ftp)(http) CSV
GSE125527_UMI_cell_table_sparse.csv.gz 187.6 Mb (ftp)(http) CSV
GSE125527_cell_id_colnames.csv.gz 357.4 Kb (ftp)(http) CSV
GSE125527_cell_metadata.csv.gz 545.8 Kb (ftp)(http) CSV
GSE125527_gene_id_rownames.csv.gz 34.1 Kb (ftp)(http) CSV
GSE125527_oldPatientId-newPatientId.csv.gz 144 b (ftp)(http) CSV
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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