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Series GSE125094 Query DataSets for GSE125094
Status Public on Jan 12, 2021
Title Manifestations of gene expression profiles in human right atrial myocardium caused by mechanical stretch
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Analysis of gene expression patterns in enlarged left atrial appendage (LAA) in mitral/aortic valve replacement or coronary artery bypass graft surgery can help to identify a comprehensive panel of gene biomarkers for predicting clinical outcomes and to discover potential new therapeutic targets. However, the transcriptional profiles triggered by extended mechanical stretch in cardiac myocytes are not fully understood. Here we performed the first genome-wide study of gene expression changes in human enlarged left atium, resulting in 335 differentially expressed (> 2-fold, P < 0,05) genes in response to mechanical stretch.
 
Overall design The study was approved by the ethics committees of Japanese Red Cross KUMAMOTO Hospital. Clinical data of the patients and those tissues were from 11 patients with enlarged left atrium (enlarged LA group) and 10 patients in normal size of atrium. (normal LA group)
Web link https://pubmed.ncbi.nlm.nih.gov/33180177/
 
Contributor(s) Ono K, Suzuki R
Citation(s) 33180177
Submission date Jan 15, 2019
Last update date Jan 12, 2021
Contact name Masaki Morishima
E-mail(s) mmoris928@yahoo.co.jp
Phone +81-88-633-9679
Organization name Clinical Research Center for Diabetes
Department Tokushima University
Street address 2-50-1, Kuramoto-cho
City Tokushima
State/province Tokushima
ZIP/Postal code 770-0861
Country Japan
 
Platforms (1)
GPL17077 Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Probe Name version)
Samples (21)
GSM3562651 31: normal size of left atrium
GSM3562652 32: normal size of left atrium
GSM3562653 33: normal size of left atrium
Relations
BioProject PRJNA515209

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE125094_335_indivi_Fold_change_.xlsx 610.7 Kb (ftp)(http) XLSX
GSE125094_All_entities_21_cases_indivi_.txt.gz 17.3 Mb (ftp)(http) TXT
GSE125094_RAW.tar 65.1 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table
Processed data are available on Series record

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