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Series GSE124854 Query DataSets for GSE124854
Status Public on Jun 27, 2019
Title RNAseq based trascript profilling of MCF7-xenograft mice treated with one of three CDK4/6 inhibitiors
Organisms Homo sapiens; Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary We compare differences in gene expression induced after treating MCF7-xenograft mice with either ribociclib, palbociclib, or abemacicilb daily for 4 days.
Overall design Mice were engrafted with MCF7 cells in each flank and allowed to grow to ~300 mm3. The animals were then randomly assigned to treatment groups, and treated daily for four days with ribociclib (150 mg/kg), palbociclib (150 mg/kg), abemaciclib (25, 75, 100, 125, or 150 mg/kg), or vehicle control (0.5% (w/v)
Contributor(s) Hafner M, Mills C, Boswell S, Subramanian K
Citation(s) 31178407
Submission date Jan 09, 2019
Last update date Jun 27, 2019
Contact name Kartik Subramanian
Organization name Harvard Medical School
Street address 200 Longwood Avenue
City Boston
ZIP/Postal code 02115
Country USA
Platforms (1)
GPL19415 Illumina NextSeq 500 (Homo sapiens; Mus musculus)
Samples (64)
GSM3557145 13L_Ribociclib_150.0
GSM3557146 13R_Ribociclib_150.0
GSM3557147 14L_Ribociclib_150.0
BioProject PRJNA514039
SRA SRP178115

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE124854_combined_counts.csv.gz 1.9 Mb (ftp)(http) CSV
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Raw data are available in SRA
Processed data are available on Series record

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