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| Status |
Public on Jun 27, 2019 |
| Title |
RNAseq based trascript profilling of MCF7-xenograft mice treated with one of three CDK4/6 inhibitiors |
| Organisms |
Homo sapiens; Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
We compare differences in gene expression induced after treating MCF7-xenograft mice with either ribociclib, palbociclib, or abemacicilb daily for 4 days.
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| Overall design |
Mice were engrafted with MCF7 cells in each flank and allowed to grow to ~300 mm3. The animals were then randomly assigned to treatment groups, and treated daily for four days with ribociclib (150 mg/kg), palbociclib (150 mg/kg), abemaciclib (25, 75, 100, 125, or 150 mg/kg), or vehicle control (0.5% (w/v)
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| Contributor(s) |
Hafner M, Mills C, Boswell S, Subramanian K |
| Citation(s) |
31178407 |
| Submission date |
Jan 09, 2019 |
| Last update date |
Jun 27, 2019 |
| Contact name |
Kartik Subramanian |
| E-mail(s) |
kartik_subramanian@hms.harvard.edu
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| Organization name |
Harvard Medical School
|
| Street address |
200 Longwood Avenue
|
| City |
Boston |
| ZIP/Postal code |
02115 |
| Country |
USA |
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| Platforms (1) |
| GPL19415 |
Illumina NextSeq 500 (Homo sapiens; Mus musculus) |
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| Samples (64)
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| Relations |
| BioProject |
PRJNA514039 |
| SRA |
SRP178115 |
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