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Series GSE124787 Query DataSets for GSE124787
Status Public on Apr 08, 2019
Title Gene Expression Changes Associated with Nintedanib Treatment in Idiopathic Pulmonary Fibrosis Fibroblasts [miRNA-seq]
Organism Homo sapiens
Experiment type Non-coding RNA profiling by high throughput sequencing
Summary We found strong protein-protein interactions within these dysregulated genes in nintedanib treated IPF fibroblast, with most genes involved in the pathways of cell cycle, mitotic cell cycle, and cell division. In IPF fibroblasts, we found nintedanib treatment was associated with downregulation of has-miR-92a-1-5p, which might de-repress SLC25A23 expression, and upregulation of has-miR-486-5p, which might repress DDX11, E2F1, and PLXNA4 expressions.
 
Overall design Next-generation sequencing for mRNA and small RNA of IPF fibroblasts treated with nintedanib 2 ╬╝M and 4 ╬╝Mnormal and without nintedanib
 
Contributor(s) Sheu C, Chang W, Kuo P, Hsu Y, Chen Y
Citation(s) 30841487
Submission date Jan 08, 2019
Last update date Apr 08, 2019
Contact name Wei An Chang
E-mail(s) 960215kmuh@gmail.com
Phone +886-982202456
Organization name Kaohsiung Medical University
Street address No.100, Shihcyuan 1st Rd., Sanmin Dist., Kaohsiung City 80708, Taiwan (R.O.C.)
City Kaohsiung
ZIP/Postal code 80708
Country Taiwan
 
Platforms (1)
GPL18573 Illumina NextSeq 500 (Homo sapiens)
Samples (3)
GSM3554073 Ctrl_IPF [small RNA-seq]
GSM3554074 Nintedanib_2uM_IPF [small RNA-seq]
GSM3554075 Nintedanib_4uM_IPF [small RNA-seq]
This SubSeries is part of SuperSeries:
GSE124788 Gene Expression Changes Associated with Nintedanib Treatment in Idiopathic Pulmonary Fibrosis Fibroblasts
Relations
BioProject PRJNA513488
SRA SRP176627

Download family Format
SOFT formatted family file(s) SOFTHelp
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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE124787_RAW.tar 280.0 Kb (http)(custom) TAR (of XLSX)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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