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| Status |
Public on Apr 08, 2019 |
| Title |
Gene Expression Changes Associated with Nintedanib Treatment in Idiopathic Pulmonary Fibrosis Fibroblasts [miRNA-seq] |
| Organism |
Homo sapiens |
| Experiment type |
Non-coding RNA profiling by high throughput sequencing
|
| Summary |
We found strong protein-protein interactions within these dysregulated genes in nintedanib treated IPF fibroblast, with most genes involved in the pathways of cell cycle, mitotic cell cycle, and cell division. In IPF fibroblasts, we found nintedanib treatment was associated with downregulation of has-miR-92a-1-5p, which might de-repress SLC25A23 expression, and upregulation of has-miR-486-5p, which might repress DDX11, E2F1, and PLXNA4 expressions.
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| Overall design |
Next-generation sequencing for mRNA and small RNA of IPF fibroblasts treated with nintedanib 2 μM and 4 μMnormal and without nintedanib
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| Contributor(s) |
Sheu C, Chang W, Kuo P, Hsu Y, Chen Y |
| Citation(s) |
30841487 |
| |
| Submission date |
Jan 08, 2019 |
| Last update date |
Apr 08, 2019 |
| Contact name |
Wei An Chang |
| E-mail(s) |
960215kmuh@gmail.com
|
| Phone |
+886-982202456
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| Organization name |
Kaohsiung Medical University
|
| Street address |
No.100, Shihcyuan 1st Rd., Sanmin Dist., Kaohsiung City 80708, Taiwan (R.O.C.)
|
| City |
Kaohsiung |
| ZIP/Postal code |
80708 |
| Country |
Taiwan |
| |
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| Platforms (1) |
| GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
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| Samples (3) |
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| This SubSeries is part of SuperSeries: |
| GSE124788 |
Gene Expression Changes Associated with Nintedanib Treatment in Idiopathic Pulmonary Fibrosis Fibroblasts |
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| Relations |
| BioProject |
PRJNA513488 |
| SRA |
SRP176627 |
