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Series GSE124188 Query DataSets for GSE124188
Status Public on Jul 08, 2019
Title Genome-wide identification of 5hmCpGs in multiple myeloma
Organism Homo sapiens
Experiment type Methylation profiling by high throughput sequencing
Summary We report the genomic localization of 5-hydroxymethylcytosines in multiple myeloma patients through the use of selective chemical labeling (SCL) and exonuclease digestion. Data highlighted super-enhancers and enhancers specifically undergoing active DNA demethylation in multiple myeloma cells.
Overall design Genomic DNA from multiple myeloma (MM) cells was extracted and submitted to the SCL-exo protocol. After sequencing with a HiSeq 1500 (Illumina), reads were mapped to hg19 and processed to generate a single-CpG signal file (wig file) indicating the relative levels of hydroxymethylation.
Contributor(s) Salbert G, Avner S
Citation(s) 31221779
Submission date Dec 20, 2018
Last update date Jul 08, 2019
Contact name Gilles Salbert
Organization name University Rennes 1
Department IGDR UMR6290
Street address 263 Av. Gal. Leclerc
City Rennes
ZIP/Postal code 35200
Country France
Platforms (1)
GPL18460 Illumina HiSeq 1500 (Homo sapiens)
Samples (24)
GSM3523586 E6068 input
GSM3523587 E6068 SCL-exo
GSM3523588 E7060 input
BioProject PRJNA510971
SRA SRP174036

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE124188_RAW.tar 518.3 Mb (http)(custom) TAR (of WIG)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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