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Series GSE124089 Query DataSets for GSE124089
Status Public on Dec 20, 2018
Title Malt1 protease is critical in maintaining function of Treg cells and may be a therapeutic target for anti-tumor immunity
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary We report that the paracaspase Malt1 is required for the development and function of Treg cells. By generating Malt1 conditional knockout and protease dead mutant mice, we found Malt1-loss in Treg cells would lead to early-onset lethal autoimmune disease and the mice would die within 40 days after birth. Interestingly, mice with Treg specific inhibition of Malt1 protease activity develop spontaneous inflammatory disorders.
 
Overall design YFP+ Treg cells sorted from WT, cKO and cKI mice were used for RNA extraction and RNA-sequencing
 
Contributor(s) Cheng L, Yang N
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Submission date Dec 19, 2018
Last update date Mar 01, 2019
Contact name Liqing Cheng
Organization name Tsinghua university
Department school of medicine
Lab Linxin lab
Street address Tsinghua University,Hai Dian, Beijing
City Beijing
State/province Beijing
ZIP/Postal code 100084
Country China
 
Platforms (1)
GPL21273 HiSeq X Ten (Mus musculus)
Samples (5)
GSM3520328 LX-ZLQ-WT-1
GSM3520329 LX-ZLQ-WT-2
GSM3520330 LX-ZLQ-KO
Relations
BioProject PRJNA510753
SRA SRP173894

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE124089_RAW.tar 6.5 Mb (http)(custom) TAR (of TXT)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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