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Status |
Public on Nov 04, 2008 |
Title |
H3K79 methylation profiles define murine and human MLL-AF4 leukemias |
Organisms |
Homo sapiens; Mus musculus |
Experiment type |
Expression profiling by array Genome binding/occupancy profiling by genome tiling array
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Summary |
We created a mouse model where conditional expression of physiologic levels of an Mll-AF4 fusion oncogene induces development of acute lymphoblastic (ALL) or acute myeloid leukemias (AML). Immunophenotypic and gene expression analysis of the ALL cells demonstrated bone marrow replacement with B-precursor cells which express a gene expression profile that has significant overlap with profiles in human MLL-rearranged ALL.
This SuperSeries is composed of the SubSeries listed below.
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Overall design |
Refer to individual Series
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Contributor(s) |
Lemieux ME |
Citation(s) |
18977325 |
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Submission date |
Aug 06, 2008 |
Last update date |
May 04, 2018 |
Contact name |
Madeleine E. Lemieux |
E-mail(s) |
mlemieux@bioinfo.ca
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Phone |
617-595-6695
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URL |
http://www.bioinfo.ca
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Organization name |
Bioinfo
|
Street address |
275 Main St., Suite 252
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City |
Plantagenet |
State/province |
ON |
ZIP/Postal code |
K0B 1L0 |
Country |
Canada |
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Platforms (3) |
GPL5082 |
[Hs_PromPR] Affymetrix Human Promoter 1.0R Array |
GPL5811 |
[Mm_PromPR] Affymetrix Mouse Promoter 1.0R Array |
GPL8321 |
[Mouse430A_2] Affymetrix Mouse Genome 430A 2.0 Array |
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Samples (49)
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This SuperSeries is composed of the following SubSeries:
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GSE12310 |
Expression profiling of normal murine lymphoid progenitors and MLL-AF4 leukemic lymphoblasts |
GSE12313 |
Expression profiling of activated or control 5-FU bone marrow from MLL-AF4stop knockin mice |
GSE12360 |
Genome-wide analysis of H3K79 methylation in CD34+ CD19+ cells from normal marrow, MLL-rearranged or MLL-germline ALL |
GSE12361 |
Genome-wide analysis of H3K79 dimethylation in normal and MLL-AF4 leukemic pre-B cells |
GSE12362 |
Genome-wide analysis of H3K79 dimethylation in MLL-AF4 leukemic bone marrow |
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Relations |
BioProject |
PRJNA113189 |