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Series GSE12363 Query DataSets for GSE12363
Status Public on Nov 04, 2008
Title H3K79 methylation profiles define murine and human MLL-AF4 leukemias
Organisms Homo sapiens; Mus musculus
Experiment type Expression profiling by array
Genome binding/occupancy profiling by genome tiling array
Summary We created a mouse model where conditional expression of physiologic levels of an Mll-AF4 fusion oncogene induces development of acute lymphoblastic (ALL) or acute myeloid leukemias (AML). Immunophenotypic and gene expression analysis of the ALL cells demonstrated bone marrow replacement with B-precursor cells which express a gene expression profile that has significant overlap with profiles in human MLL-rearranged ALL.

This SuperSeries is composed of the SubSeries listed below.
 
Overall design Refer to individual Series
 
Contributor(s) Lemieux ME
Citation(s) 18977325
Submission date Aug 06, 2008
Last update date May 04, 2018
Contact name Madeleine E. Lemieux
E-mail(s) mlemieux@bioinfo.ca
Phone 617-595-6695
URL http://www.bioinfo.ca
Organization name Bioinfo
Street address 275 Main St., Suite 252
City Plantagenet
State/province ON
ZIP/Postal code K0B 1L0
Country Canada
 
Platforms (3)
GPL5082 [Hs_PromPR] Affymetrix Human Promoter 1.0R Array
GPL5811 [Mm_PromPR] Affymetrix Mouse Promoter 1.0R Array
GPL8321 [Mouse430A_2] Affymetrix Mouse Genome 430A 2.0 Array
Samples (49)
GSM309474 pro-B4
GSM309475 pro-B5
GSM309476 pro-B6
This SuperSeries is composed of the following SubSeries:
GSE12310 Expression profiling of normal murine lymphoid progenitors and MLL-AF4 leukemic lymphoblasts
GSE12313 Expression profiling of activated or control 5-FU bone marrow from MLL-AF4stop knockin mice
GSE12360 Genome-wide analysis of H3K79 methylation in CD34+ CD19+ cells from normal marrow, MLL-rearranged or MLL-germline ALL
Relations
BioProject PRJNA113189

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE12363_RAW.tar 775.2 Mb (http)(custom) TAR (of BAR, BED, CEL)
Raw data provided as supplementary file
Processed data included within Sample table

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