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Status |
Public on Nov 04, 2008 |
Title |
Expression profiling of normal murine lymphoid progenitors and MLL-AF4 leukemic lymphoblasts |
Organism |
Mus musculus |
Experiment type |
Expression profiling by array
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Summary |
We created a mouse model where conditional expression of physiologic levels of an Mll-AF4 fusion oncogene induces development of acute lymphoblastic (ALL) or acute myeloid leukemias (AML). Immunophenotypic and gene expression analysis of the ALL cells demonstrated bone marrow replacement with B-precursor cells which express a gene expression profile that has significant overlap with profiles in human MLL-rearranged ALL.
Keywords: Cell type comparison
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Overall design |
Total RNA from normal pro-B, pre-B, immature B and mature B lymphocytes, and from leukemic pre-B cells was isolated and hybridized to Affymetrix expresison microarrays.
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Contributor(s) |
Lemieux ME |
Citation(s) |
18977325 |
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Submission date |
Jul 31, 2008 |
Last update date |
May 04, 2018 |
Contact name |
Madeleine E. Lemieux |
E-mail(s) |
mlemieux@bioinfo.ca
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Phone |
617-595-6695
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URL |
http://www.bioinfo.ca
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Organization name |
Bioinfo
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Street address |
275 Main St., Suite 252
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City |
Plantagenet |
State/province |
ON |
ZIP/Postal code |
K0B 1L0 |
Country |
Canada |
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Platforms (1) |
GPL8321 |
[Mouse430A_2] Affymetrix Mouse Genome 430A 2.0 Array |
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Samples (39)
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This SubSeries is part of SuperSeries: |
GSE12363 |
H3K79 methylation profiles define murine and human MLL-AF4 leukemias |
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Relations |
BioProject |
PRJNA113843 |