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Series GSE12310 Query DataSets for GSE12310
Status Public on Nov 04, 2008
Title Expression profiling of normal murine lymphoid progenitors and MLL-AF4 leukemic lymphoblasts
Organism Mus musculus
Experiment type Expression profiling by array
Summary We created a mouse model where conditional expression of physiologic levels of an Mll-AF4 fusion oncogene induces development of acute lymphoblastic (ALL) or acute myeloid leukemias (AML). Immunophenotypic and gene expression analysis of the ALL cells demonstrated bone marrow replacement with B-precursor cells which express a gene expression profile that has significant overlap with profiles in human MLL-rearranged ALL.

Keywords: Cell type comparison
 
Overall design Total RNA from normal pro-B, pre-B, immature B and mature B lymphocytes, and from leukemic pre-B cells was isolated and hybridized to Affymetrix expresison microarrays.
 
Contributor(s) Lemieux ME
Citation(s) 18977325
Submission date Jul 31, 2008
Last update date May 04, 2018
Contact name Madeleine E. Lemieux
E-mail(s) mlemieux@bioinfo.ca
Phone 617-595-6695
URL http://www.bioinfo.ca
Organization name Bioinfo
Street address 275 Main St., Suite 252
City Plantagenet
State/province ON
ZIP/Postal code K0B 1L0
Country Canada
 
Platforms (1)
GPL8321 [Mouse430A_2] Affymetrix Mouse Genome 430A 2.0 Array
Samples (39)
GSM309474 pro-B4
GSM309475 pro-B5
GSM309476 pro-B6
This SubSeries is part of SuperSeries:
GSE12363 H3K79 methylation profiles define murine and human MLL-AF4 leukemias
Relations
BioProject PRJNA113843

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE12310_RAW.tar 77.6 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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